Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults
| Status: | Completed |
|---|---|
| Conditions: | Orthopedic |
| Therapuetic Areas: | Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 8/9/2017 |
| Start Date: | November 2011 |
| End Date: | March 2017 |
Muscle proteins accumulate damage during aging and leads to the loss of muscle mass and
function in older people. Exercise can increase the making of new proteins and removal of
older proteins, but it is not known if the effect changes with aging or type of exercise. The
investigators will determine the ability for endurance, resistance, or a combination of
exercise training to remove older-damaged proteins and make newer-functional muscle proteins
in groups of younger and older people. The investigators will particularly study protein that
are involved with energy production (mitochondrial proteins) and force production
(contractile proteins).
Hypothesis 1: Older people will have greater accumulation of damaged proteins than younger
people.
Hypothesis 2: Aerobic exercise will decrease the accumulation of damaged forms of contractile
and mitochondrial proteins in younger and older people.
Hypothesis 3: Resistance exercise will decrease the accumulation of damaged forms of
contractile proteins in younger and older people.
function in older people. Exercise can increase the making of new proteins and removal of
older proteins, but it is not known if the effect changes with aging or type of exercise. The
investigators will determine the ability for endurance, resistance, or a combination of
exercise training to remove older-damaged proteins and make newer-functional muscle proteins
in groups of younger and older people. The investigators will particularly study protein that
are involved with energy production (mitochondrial proteins) and force production
(contractile proteins).
Hypothesis 1: Older people will have greater accumulation of damaged proteins than younger
people.
Hypothesis 2: Aerobic exercise will decrease the accumulation of damaged forms of contractile
and mitochondrial proteins in younger and older people.
Hypothesis 3: Resistance exercise will decrease the accumulation of damaged forms of
contractile proteins in younger and older people.
The loss of muscle mass and function with age leads to high social and economic costs.
Lifestyle interventions that can help maintain muscle mass and function can be beneficial to
improve health and decrease the costs associated with loss of independence in the elderly.
Muscle proteins accumulate damage during aging, which is suggested to lead to loss of
function. The biological processes that remove damaged proteins and synthesis new proteins
appear to be decreased with aging. Exercise is known to increase the processes that remove
older and synthesis newer muscle proteins and may be an effect lifestyle intervention to
improve muscle quality and function. Additionally, specific types of proteins appear to decay
with age including contractile and mitochondrial proteins. Different types of exercise
training can increase the making of specific proteins. The investigators will examine the
ability for aerobic and resistance training to increase the quality of mitochondrial and
contractile proteins between younger and older people.
Lifestyle interventions that can help maintain muscle mass and function can be beneficial to
improve health and decrease the costs associated with loss of independence in the elderly.
Muscle proteins accumulate damage during aging, which is suggested to lead to loss of
function. The biological processes that remove damaged proteins and synthesis new proteins
appear to be decreased with aging. Exercise is known to increase the processes that remove
older and synthesis newer muscle proteins and may be an effect lifestyle intervention to
improve muscle quality and function. Additionally, specific types of proteins appear to decay
with age including contractile and mitochondrial proteins. Different types of exercise
training can increase the making of specific proteins. The investigators will examine the
ability for aerobic and resistance training to increase the quality of mitochondrial and
contractile proteins between younger and older people.
Inclusion Criteria:
- Healthy
- 18 to 30 years or 65 to 80 years old
- Male and female
Exclusion Criteria:
- Regular exercise program
- Smoking
- Metabolic disease (diabetes, cardiovascular disease, cancer, thyroid disorders)
- Pregnancy
- Inability to exercise
- Overweight or obesity
- Drugs known to impair metabolic function (statin, beta-blocker, anti-inflammatory)
- Allergies to lidocaine
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