The Adjunctive Ventricular Arrhythmia Suppression Trial (AVAST) Pilot
| Status: | Completed |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 2/4/2013 |
| Start Date: | February 2011 |
| End Date: | June 2012 |
The Pharmacokinetics and Electrocardiographic Implications of Adjunctive Amiodarone and Ranolazine Therapy in Patients on Implantable Cardioverter Defibrillators: The Adjunctive Ventricular Arrhythmia Suppression Trial (AVAST) Pilot
The purpose of this study is to learn if combination therapy with amiodarone and ranolazine
(an approved drug for chest pain) can help prevent arrhythmias.
Inclusion Criteria:
- Patients with an ICD who were on a stable dose of amiodarone for the past 60 days
Exclusion Criteria:
- Patients with a life expectancy of less than 6 months
- Patients with moderate or severe hepatic impairment (Child-Pugh Classes B or C) or
requiring hemodialysis.
- Pregnancy or lactation.
- Treatment with potent CYP3A inhibitors, including ketoconazole, itraconazole,
clarithromycin, nefazodone, nelfinavir, indinavir, and saquinavir
- Treatment with CYP3A inducers, including rifampin, rifabutin, rifapentine,
phenobarbital, phenytoin, carbamazepine, and St. John's wort.
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