Integrating the Genetic and Metabolic Faces of Obesity
| Status: | Completed |
|---|---|
| Conditions: | Obesity Weight Loss, Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 30 - 65 |
| Updated: | 11/30/2013 |
| Start Date: | October 2005 |
| End Date: | December 2009 |
| Contact: | Tracey McLaughlin, MD, MS |
| Phone: | 650-723-7024 |
The goal of this study is to determine why some obese individuals develop insulin resistance
and others do not. We hypothesize that an impairment in differentiation of fat cells
(adipocytes) is responsible for the development of insulin resistance in select obese
individuals. This study will evaluate obese individuals at baseline with respect to
characteristics of adipocytes, including gene expression, and will then entail randomizing
subjects to either weight loss or treatment with an insulin sensitizing drug (pioglitazone).
Changes in insulin resistance will be associated with changes in adipocyte morphology and
gene expression.
Healthy overweight/obese individuals will be screened for insulin resistance. Both insulin
resistant individuals and insulin sensitive individuals (to serve as controls) will be
eligible to enroll. Fat cel biopsy and CT scan of the abdomen is required at baseline and
after an intervention with either weight loss or pioglitazone (drug to improve insulin
resistance). Subjects will repeat insulin resistance test after the intervention as well.
Subjects will learn much about their metabolism in this study, and will have an opportunity
to improve their insulin resistance.
Inclusion Criteria:
- nondiabetic defined as fasting plasma glucose < 126 mg/dL
- body mass index 27 to 35 kg/m2
- no major organ diseases
- able to come to Stanford for regular clinical research center visits
- English speaking or has own translator
Exclusion Criteria:
- pregnancy/lactation
- history of eating disorder or major psychiatric illness
- allergy to thiazolidenedione
- elevation of liver enzymes (> 2.5 times upper normal limit)
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Stanford University Stanford University, located between San Francisco and San Jose in the heart of...
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