A Study To Evaluate The Effect Of CP-690,550 On Measures Of Kidney Function In Patients With Active Rheumatoid Arthritis



Status:Completed
Conditions:Arthritis, Rheumatoid Arthritis
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:Any
Updated:10/21/2012
Start Date:April 2012
End Date:November 2013
Contact:Pfizer CT.gov Call Center
Phone:1-800-718-1021

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A Phase 1, Randomized, Placebo-Controlled, Two-Period, Fixed Sequence Study To Evaluate The Effect Of CP-690,550 On Measured Glomerular Filtration Rate In Patients With Active Rheumatoid Arthritis


The purpose of study is to explore the effect of CP-690,550 (Tofacitinib) on measures of
kidney function in patients with active rheumatoid arthritis (RA).


Inclusion Criteria:

- The patient must meet the American College of Rheumatology (ACR) classification
criteria for the diagnosis of rheumatoid arthritis by satisfying at least four of the
seven criteria.

- The patient must have active disease at both Screening and predose on Day 1 of Period
1.

- Patient must have had an inadequate response to at least one disease-modifying
antirheumatic drug (DMARD), non-biologic or biologic, due to ineffectiveness or
intolerance.

Exclusion Criteria:

- Pregnant or lactating women

- Serious medical conditions that would make treatment with CP-690,550 potentially
unsafe.

- A patient who has a history of asthma, multiple allergies or severe allergy (eg,
anaphylaxis) to any substance. In particular, a history of allergy to iodine,
povidone-iodine, iohexol or other iodinated contrast media.
We found this trial at
5
sites
Pittsburgh, Pennsylvania 15212
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Pittsburgh, PA
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Atlantis, Florida 33462
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Atlantis, FL
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Houston, Texas 77030
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Houston, TX
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Rochester, New York 14642
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Rochester, NY
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Seattle, Washington 98166
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Seattle, WA
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