A Study of the HSP90 Inhibitor AUY922

Study Drug Administration:

If you are found to be eligible to take part in this study, you will receive AUY922 by vein
over about 1 hour on Days 1, 8, 15, and 22 of each 28-day cycle.

Study Visits:

On Days 1 and 15 of Cycles 1-12:

- You will have a physical exam, including measurement of your vital signs (blood
pressure, heart rate, temperature, and breathing rate).

- Your performance status will be recorded.

- You will be asked about any drugs you may be taking and any side effects you may have
had.

- Blood (about 6-7 teaspoons) will be drawn for routine tests. On Day 1 of Cycle 1, this
blood will also be used to check your heart function.

- You will have ECGs before and after the study drug infusion.

On Day 8 of Cycles 1-12:

- Your vital signs will be measured.

- You will be asked about any drugs you may be taking and any side effects you may have
had.

- Blood (about 6-7 teaspoons) will be drawn for routine tests and to check your heart
function.

- You will have ECGs before and after the study drug infusion.

On Day 1 of Cycles 1 and 2:

- Urine will be collected for routine tests.

- Blood (about 1 teaspoon) will be drawn to check your blood clotting function.

On Days 2 and 3 of Cycle 1:

- Blood (about 5-6 teaspoons) will be drawn for routine tests.

- You will have ECGs at about 24 and 48 hours after the end of the infusion.

- You will be asked about any drugs you may be taking, any side effects you may be
having, and about your overall health.

On Day 22 of Cycle 1:

- You will have a physical exam, including measurement of your vital signs.

- Your performance status will be recorded.

- You will be asked about any drugs you may be taking, any side effects you may be
having, and about your overall health.

- Blood (about 5-6 teaspoons) will be drawn for routine tests.

After every 2 cycles:

- You will have CT and PET scans to check the status of the disease.

- You will be asked about any side effects you may be having and about your overall
health.

Anytime the study doctor thinks it is needed, you will have an eye exam or other tests.

Length of Study:

You may continue taking AUY922 for up to 12 cycles. You will no longer be able to take the
study drug if the disease gets worse, if intolerable side effects occur, or if you are
unable to follow study directions.

End-of-Treatment Visit:

At 28 days after your last dose:

- Blood (about 5-6 teaspoons) and urine will be collected for routine tests.

- Blood (about 1 teaspoon) will be drawn to check your blood clotting function.

- You will have a physical exam, including measurement of your vital signs.

- Your performance status will be recorded.

- You will have an eye exam by an eye doctor.

- You will have CT and PET scans to check the status of the disease.

- You will be asked about any drugs you may be taking, any side effects you may be
having, and about your overall health.

Long-Term Follow-Up:

After you stop the study drug, you will have a CT scan and physical exam every 3 months for
1 year, then every 4 months for another year, and every 6 months for 3 years and then 1 time
a year after that.

This is an investigational study. AUY922 is not FDA approved or commercially available. It
is currently being used for research purposes only.

Up to 42 patients will take part in this study. All will be enrolled at MD Anderson.

Inclusion Criteria:

1. Age >/= 18 years

2. Able to sign Informed Consent

3. Patients must have the following laboratory values: Hematologic: Absolute Neutrophil
Count (ANC) >/=1.5x10^9/L; Hemoglobin (Hgb) >/=9 g/dl; Platelets (plt) >/=50 x10^9/L.
Biochemistry: Potassium within normal limits; Total calcium (corrected for serum
albumin) and Phosphorus within normal limits o Magnesium above LLN or correctable
with supplements; Liver and Kidney Functions: aspartate aminotransferase (AST)/serum
glutamate oxaloacetate transaminase (SGOT) and ALT/serum glutamate pyruvate
transaminase (SGPT)
2.5 ULN AST/SGOT and ALT/SGPT Phosphate (AP) x ULN; Serum creatinine /= 50 ml/min.

4. Negative serum pregnancy test. The serum pregnancy test must be obtained prior to the
first administration of AUY922 ( women and women <2 years after the onset of menopause

5. Histologically confirmed Diffuse Large B-cell Lymphoma (DLBCL), (primary mediastinal
DLBCL, DLBCL-NOS, large B-cell transformation of indolent B-cell lymphoma including
follicular lymphoma, small lymphocytic lymphoma and marginal zone lymphoma) or
Peripheral T-cell Lymphoma (PTCL), including PTCL not otherwise specified,
angioimmunoblastic lymphoma, anaplastic large T-cell lymphoma, hepatosplenic T-cell
lymphoma, enteropathy associated T-cell lymphoma; nodal or extranodal NK/T-cell
lymphoma, mycosis fungoides with radiographically measurable disease.

6. Relapsed or refractory after standard treatments and with no curative option with
conventional therapy.

7. Measurable disease.

8. No known evidence of cerebral or meningeal involvement by lymphoma.

9. Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2.

Exclusion Criteria:

1. Diarrhea > CTCAE (v4.02) grade 1 that cannot be controlled with oral anti-diarrhea
medications.

2. Pregnant or lactating women.

3. Fertile women of childbearing potential (WCBP), a female that has not been surgically
sterilized or that has not been amenorrheic for at least 24 consecutive months, not
using double-barrier methods of contraception (abstinence, oral contraceptives,
intrauterine device or barrier method of contraception in conjunction with
spermicidal jelly, or surgically sterile). Male patients whose partners are WCBP not
using double-barrier methods of contraception.

4. Impaired cardiac function, including any one of the following: History (or family
history) of long QT syndrome; Mean QTc >/= 450 msec on baseline ECG; History of
clinically manifested ischemic heart disease History of heart failure or left ventricular (LV) dysfunction (LVEF multigated radionuclide angiography (MUGA) or ECHO; Clinically significant ECG
abnormalities including 1 or more of the following: left bundle branch block (LBBB),
right bundle branch block (RBBB) with left anterior hemiblock (LAHB). ST segment
elevation or depression > 1mm, or 2nd (Mobitz II), or 3rd degree AV block.

5. Continuation #4) History or presence of atrial fibrillation, atrial flutter or
ventricular arrhythmias including ventricular tachycardia or Torsades de Pointes;
Other clinically significant heart disease (e.g. congestive heart failure,
uncontrolled hypertension (2 consecutive reading >140/90), history of labile
hypertension, or history of poor compliance with an antihypertensive regimen);
Clinically significant resting bradycardia (< 50 beats per minute); Patients who are
currently receiving treatment with any medication which has a relative risk of
prolonging the QTcF interval or inducing Torsades de Pointes and cannot be switched
or discontinued to an alternative drug prior to commencing AUY922;

6. Obligate use of a cardiac pacemaker.

7. All lymphomas except for Diffuse Large B-cell Lymphoma (DLBCL) and Peripheral T-cell
Lymphoma (PTCL).

8. Chemotherapy or radiation therapy or other investigational agents within 3 weeks
prior to entering the study.

9. Previous radioimmunotherapy within 12 weeks.

10. Patient with known HIV infection.

11. Known active viral hepatitis.

12. Any serious active disease or co-morbid condition, which in the opinion of the
principle investigator, will interfere with the safety or with compliance with the
study.

13. Serious nonmalignant disease (e.g., congestive heart failure, hydronephrosis); active
uncontrolled bacterial, viral, or fungal infections; or other conditions which would
compromise protocol objectives in the opinion of the investigator.