Sinusitis in Children and the Nasopharyngeal Microbiome
| Status: | Completed |
|---|---|
| Conditions: | Sinusitis |
| Therapuetic Areas: | Otolaryngology |
| Healthy: | No |
| Age Range: | 4 - 7 |
| Updated: | 5/10/2018 |
| Start Date: | January 2012 |
| End Date: | June 2017 |
My Nose Study: Sinusitis in Children and How Virus Infections Promote Secondary Bacterial Infections
The purpose of this study is to investigate the relationship between viral infections of the
upper respiratory tract, perturbations of the nasopharyngeal microbiome in children, and the
risk of acute bacterial sinusitis over a one year period. The investigators will determine
the incidence of acute bacterial sinusitis post viral upper respiratory infection and
identify the viral antecedent infections and other risk factors which predispose to infection
and ultimately design strategies to reduce the burden of disease and antimicrobial
resistance.
upper respiratory tract, perturbations of the nasopharyngeal microbiome in children, and the
risk of acute bacterial sinusitis over a one year period. The investigators will determine
the incidence of acute bacterial sinusitis post viral upper respiratory infection and
identify the viral antecedent infections and other risk factors which predispose to infection
and ultimately design strategies to reduce the burden of disease and antimicrobial
resistance.
Inclusion Criteria:
- Children 4 to 7 years of age
- Healthy
- English-speaking parent/guardian -
Exclusion Criteria:
- Any underlying condition which would predispose them to the development of sinusitis
including congenital or acquired immunodeficiencies
- Craniofacial abnormalities
- Cystic fibrosis
- Allergic rhinitis or a previous episode of chronic sinusitis.
We found this trial at
2
sites
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