A Longitudinal Study of Amyotrophic Lateral Sclerosis (ALS) Biomarkers

Status:	Recruiting
Conditions:	Neurology, Orthopedic, ALS
Therapuetic Areas:	Neurology, Orthopedics / Podiatry, Other
Healthy:	No
Age Range:	18 - Any
Updated:	6/4/2016
Start Date:	November 2011
End Date:	December 2016
Contact:	Daniela Grasso
Email:	dgrasso@partners.org
Phone:	617-726-0842

A Multicenter Study for the Discovery and Validation of ALS Biomarkers

The purpose of this study is to collect biofluid samples for the banking and usage in ALS
research. Through comparison of these samples, the researchers hope to learn more about the
underlying cause of ALS, as well as find unique biological markers, which could be used to
develop new therapies.

The purpose of the research study is to collect blood samples and cerebrospinal fluid (CSF)
from people with amyotrophic lateral sclerosis (ALS). These samples will be collected
approximately every 4 months.

Inclusion Criteria:

- Age 18 or older

- Diagnosis of suspected, possible, probable or definite ALS according to El Escorial
Criteria

- Vital capacity (VC) at least 50 percent predicted

- Able to undergo multiple lumbar punctures

Exclusion Criteria:

- Abnormal CSF pressure or intracranial/intraspinal tumors

- Use of anticoagulant medication that cannot be safely withheld

- Bleeding disorders

- This is a partial listing.

We found this trial at

sites

Emory University

201 Dowman Dr
Atlanta, Georgia 30303

(404) 727-6123