Effects of Calorie Restriction on Accumulation of Old, Modified Proteins in Abdominally Obese Adults
| Status: | Completed |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 45 - 65 |
| Updated: | 2/7/2015 |
| Start Date: | December 2011 |
| End Date: | December 2014 |
This study is being done to understand the effects of calorie restriction and weight loss on
muscle protein metabolism in adult men and women.
muscle protein metabolism in adult men and women.
Inclusion Criteria:
- Healthy
- BMI will be between 30 kg/m2 - 38 kg/m2 and waist circumference for women ≥ 88 cm and
men ≥ 104 cm
- Age 45 to 65 years.
- Male and Female
Exclusion Criteria:
- Active coronary artery disease
- BMI < 30 kg/m2 Participation in structured exercise (>2 times per week for 30 minutes
or longer)
- Smoking
- Medications known to affect muscle metabolism (beta blockers)
- Renal failure (serum creatinine > 1.5mg/dl)
- Chronic active liver disease (AST and ALT > 3 times normal)
- Fasting blood glucose > 126 mg/dl
- Anti-coagulant therapy (warfarin/heparin)
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