Photoacoustic Endoscopy in Endometrial Cancer

The investigators will evaluate whether this technology can be used and also try to obtain
photoacoustic images and functional data (oxygen contents, blood vessel characteristics,
etc) of the uterine lining to assess its appearance in women with and without cancer of the
endometrium. Currently, it is difficult for physicians to know whether or not tumors of the
endometrium have invaded and spread to other organs without performing an extended surgery
called a staging operation (removal of the lymph nodes or glands that drain the uterus to
assess under the microscope whether or not the cancer has spread). Our long term goal is to
use this new photoacoustic (PA) technology to improve detection of occult metastatic
disease. Occult disease is defined as tumor which cannot be seen without the use of imaging
techniques. and possibly avoid the need of extended operations. All of this could result in
better care for patients with endometrial cancer and other gynecologic problems.

Inclusion Criteria:

- Women diagnosed with benign gynecologic pathology (N=10) or biopsy proven endometrial
cancer (N=10) who will undergo hysterectomy.

- Participants must be ≥ 18 years of age.

- Subjects of reproductive potential must have a negative pregnancy test prior to study
photoacoustic endoscopy procedure and hysterectomy.

- Subjects must be able understand and willing to sign a written informed consent form.

Exclusion Criteria:

- Subjects with contraindications for general anesthesia or hysterectomy.

- Subjects with evidence of active pelvic inflammatory disease or purulent cervicitis.

- Subjects with prior endometrial ablation procedures.

- Gross tumoral involvement of the cervix or lower genital tract precluding cervical
dilatation and endometrial sounding.