A Single Ascending Dose Study Examining the Safety and Pharmacokinetic Profile of Reconstituted High Density Lipoprotein (CSL112) Administered to Patients
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/18/2012 |
| Start Date: | February 2012 |
| Contact: | Clinical Trials Registration Coordinator |
| Email: | csl.clinicaltrials@csl.com.au |
A Phase 2a, Multi-center, Randomized, Double-blind, Placebo-controlled, Single Ascending Dose Study to Investigate the Safety, Tolerability and Pharmacokinetics of a Single Intravenous Infusion of CSL112 in Patients With Stable Atherothrombotic Disease
Reconstituted high density lipoprotein used in patients with acute coronary syndrome (ACS)
may reduce atherosclerotic plaque burden, thereby reducing the risk of recurrent
cardiovascular events. This study is a multi-center, randomized, placebo-controlled, single
ascending dose study in patients with stable atherothrombotic disease in whom the safety and
pharmacokinetic profile of CSL112 will be assessed.
Inclusion Criteria:
- Male or female aged 18 years to 80 years.
- Subjects must have documented evidence of a history of atherosclerotic coronary
artery disease/surgical revascularization.
- Subjects on a stable medication regimen.
- Body weight 50 kg or greater at screening.
Exclusion Criteria:
- Moderate/severe heart failure or renal impairment.
- Uncontrolled hyperglycemia in subjects with type 1 or type 2 diabetes.
- Receipt of the combination of omeprazole and clopidogrel within 1 month of
randomization.
- Subjects whose medical history, condition or medication regimen may interfere with
the evaluation of the safety and tolerability of CSL112 (for example significantly
altered electrocardiogram (ECG) waveform, hepatobiliary disease, malignancy,
thrombocytopenia, etc.)
- Known hypersensitivity to the product components
We found this trial at
9
sites
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