A Study to Evaluate the Efficacy and Safety of VX-765 in Subjects With Treatment-Resistant Partial Epilepsy

Part A and Part B Inclusion Criteria:

- Males or females aged 18 to 64 years with a body mass index between 18 and 35 (kg/m2)

- Subjects who have completed the assigned study treatment in Part A may enter Part B
if eligible per protocol

- Male or female subjects must agree to use acceptable contraceptive methods, as
described in the protocol

- Must have a diagnosis and history of treatment-resistant partial-onset epilepsy for
which they are taking 1 to 4 concomitant AEDs at the time of Screening Period

- Have had at least 1 electroencephalogram consistent with partial epilepsy

- Must have had at least 6 partial-onset seizures and a seizure-free period of no more
than 3 weeks (21 days) during the Baseline Period.

- Subjects with stable medical conditions (e.g., cannot have a condition that will
interfere with the conduct of the study or cause a known increase in risk of the
intervention) as determined by the principal investigator

- Must be able and willing to provide written informed consent to participate

- Must be able to understand and comply with protocol requirements and instructions

Part A and Part B Exclusion Criteria:

- Subjects who are male and their female partner (if of childbearing potential) does
not agree to use medically approved methods of contraception as described in the
protocol for the duration od the study and for 90 days after last dose of study drug

- Subjects who are male and have a female partner who is pregnant, nursing, or is
planning to become pregnant during the study period, or within 90 days of the last
dose of study drug.

- Subjects who are pregnant or lactating, or who are of reproductive potential who do
not agree to use medically approved birth control methods

- History of nonepileptic, transient alterations in consciousness

- History of status epilepticus in the past 12 months before the screening visit

- Subjects whose seizure frequency cannot be quantified (i.e. seizures with no discrete
beginning or end, or period between seizures)

- Subjects who have a significant medical illness including kidney, liver, pulmonary,
or gastrointestinal disease; or unstable or poorly controlled conditions such as
hypertension, diabetes, or angina pectoris, as judged by the investigator.

- Have a clinically significant psychiatric illness as judged by the investigator

- Subjects who have had an active suicidal plan/intent or active suicidal thoughts, or
suicide attempt as defined in the protocol

- Clinically significant laboratory abnormalities during the Screening Visit/Baseline
Period, as judged by the investigator

- Subjects who have had serious adverse events (SAEs) thought to be related to study
drug that led to discontinuation during Part A may not participate in Part B

- Active hepatitis B, hepatitis C, or human immunodeficiency virus

- Positive drug screen at screening or during the Baseline Period (excluding any
allowed prescribed medications) and/or a history of alcoholism or drug addiction
within past 2 years

- Subjects on felbamate with fewer than 18 month of continuous felbamate exposure at
the time of the Screening Visit or with significant adverse reactions to felbamate

- Subjects treated with vigabatrin fewer than 2 years prior to the Screening Visit or
who have a prior history of treatment with vigabatrin without a documented stable
examination by an ophthalmologist as defined in the protocol

- Using prohibited medications or treated with any systemic immunosuppressant

- Have experienced a symptomatic viral, fungal, or bacterial infection requiring
systemic treatment within 7 days prior to the first dose of study drug

- A current or prior history of illness precluding them from immunomodulatory therapy
(e.g., history of recurrent infections)

- Have donated any blood or have had a significant loss of blood (500 mL) as defined in
the protocol

- Have participated in any other clinical studies involving an investigational product
or device and have received the last dose of the study drug associated with that
clinical study within 30 days or 5 half-lives (whichever is longer) of the Screening
Visit

- Have participated in earlier VX-765 clinical studies and received at least one dose
of study drug

- Subjects who have no completed the full 13-week Treatment Period in part A may not
participate in Part B

- Any subject judged by the investigator, sponsor or designee to be inappropriate for
the study