High Resolution Optical Imaging of Barrett's Esophagus Using Nvision Volumetric Laser Endomicroscopy (VLE)

Inclusion Criteria:

- Males and females over the age of 18 years.

- Patients with either suspected BE presenting for endoscopy or patients with
documented BE presenting for follow-up endoscopy likely to require a biopsy or
patients presenting for endoscopy for non-BE related conditions other than esophageal
varices.

- Ability to provide written, informed consent.

- Females who are able to become pregnant, are willing to take a pregnancy test.

Exclusion Criteria:

- Patients on anticoagulation undergoing high risk procedures in accordance to American
Society For Gastrointestinal Endoscopy (ASGE) guideline for the management of
antithrombotic agents for endoscopic procedures (2009).

- Patients with esophageal varices that preclude biopsies.

- Presence of an esophageal mass that precludes full distention of the balloon from the
Nvision balloon guide sheath.

- Patients with esophageal strictures that would prevent adequate expansion of the
balloon from the Nvision balloon guide sheath.

- Patients with known inflammatory disease, esophageal tears or ulcers, which would
prohibit full distention of the balloon from the Nvision balloon guide sheath.

- Patients with known eosinophilic esophagitis.

- Patients that are pregnant.

- Patients with a history of hemostasis disorders.