Quantitative EEG Assessment of Cue-Induced Changes in Brain Activity in Alcohol Use Disorders

Inclusion Criteria:

1. Male or female, aged 21 to 70.

2. History of heavy drinking: Defined as at least 8 occasions in the past month that
individual had at least 5 drinks (males) or 4 drinks (females) in one sitting.

3. The subject must currently not be in treatment for any alcohol use disorder

4. Subject must be able to comprehend and perform study related information and tasks in
English and have a willingness to complete study procedures.

5. Subject must be able to provide written informed consent, at time of consent BAC has
to be 0.00%.

6. The subject must have the ability to read/speak English

Exclusion Criteria:

1. Severe impairment of sight, smell, or hearing that would result in a significant
alteration in the response to alcohol related cues.

2. Currently on a medication used to treat alcoholism or is known to alter EEG activity
or responsiveness to cue presentation including acamprosate, anticonvulsants,
anticholinergics, antipsychotics, benzodiazepine receptor agonists, beta adrenergic
receptor antagonists, and naltrexone.

3. History of any neurological or psychiatric disorder that would result in abnormal EEG
activity such as severe brain trauma, seizure disorders, stroke or that would severly
alter response to the cue presentation such as schizophrenia or any other psychotic
or severe mood disorder.

4. CIWA-AR score of 8 or higher or any history indicating that the subject is at risk
for experiencing severe alcohol withdrawal symptoms if her or his drinking is
discontinued for any period of time.

5. The subject must not be pregnant. -