Intra-op Detection of Occult Ovarian Carcinoma Using a Folate-Alpha Receptor Specific Fluorescent Ligand

Prognosis for many carcinomas, including ovarian carcinoma, is dependent on a complete
surgical resection, also known as a R0 resection. At present, the ability to perform a
complete resection with negative margins is limited by the surgeon's ability to palpate and
visualize the tumor and its margins. Therefore, in order to reduce operative morbidity and
costs while maintaining or improving surgical and oncologic outcomes, the investigators must
develop technologies that improve visualization of the primary tumor and occult metastases,
real time, during surgery. Recent research has demonstrated that the use of fluorescent
probes that recognize cancer specific antigens can be used for this purpose when visualized
using a prototype near-infrared multispectral imaging system.

This investigation will determine if folate-FITC, a fluorescent probe that recognizes the
folate receptor (present in > 90% of ovarian cancers) can facilitate surgical resection and
detect tumor nodules not visible to the naked eye.