Brain-imaging and Adolescent Neuroscience Consortium

The overall specific aims of this study are to: 1) assess the short and long-term
consequences of alcohol exposure on brain, cognitive, and emotional/regulatory development
during preadolescence and adolescence; 2) determine the effects of timing, dose, and
duration of alcohol on brain and cognitive development; 3) assess recovery of neural and
behavioral function to determine if the plasticity of the adolescent brain makes it more or
less vulnerable to alcohol's acute and chronic effects; 4) understand how other key
covariates (e.g., existing or emerging psychopathology, family history of alcoholism,
demographics, pubertal development) factor into alcohol's effects on the brain; and 5)
identify early neural, cognitive, and affective markers that may predict alcohol abuse and
dependence during adolescence and/or adulthood.

Inclusion Criteria:

- able to read and understand English

- available for follow-up

- parental consent/adolescent assent for those 12-17 years

- consent for those 18-21 years

Exclusion Criteria:

- Weight > 300 lbs

- braces or unremovable embedded metal

- claustrophobia or inability to lie still in MRI machine

- current or past 12-mos pregnancy (females)

- requires urgent medical/mental health care