PROSPECT: Chemotherapy Alone or Chemotherapy Plus Radiation Therapy in Treating Patients With Locally Advanced Rectal Cancer Undergoing Surgery
Status: | Active, not recruiting |
---|---|
Conditions: | Colorectal Cancer, Cancer |
Therapuetic Areas: | Oncology |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 3/7/2019 |
Start Date: | January 2012 |
A Phase II/III Trial of Neoadjuvant FOLFOX With Selective Use of Combined Modality Chemoradiation Versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection With Total Mesorectal Excision (PROSPECT)
The standard treatment for locally advanced rectal cancer involves chemotherapy and
radiation, known as 5FUCMT, (the chemotherapy drugs 5-fluorouracil/capecitabine and radiation
therapy) prior to surgery. Although radiation therapy to the pelvis has been a standard and
important part of treatment for rectal cancer and has been shown to decrease the risk of the
cancer coming back in the same area in the pelvis, some patients experience undesirable side
effects from the radiation and there have been important advances in chemotherapy, surgery,
and radiation which may be of benefit. The purpose of this study is to compare the effects,
both good and bad, of the standard treatment of chemotherapy and radiation to chemotherapy
using a combination regimen known as FOLFOX, (the drugs 5-fluorouracil (5-FU), oxaliplatin
and leucovorin) and selective use of the standard treatment, depending on response to the
FOLFOX. The drugs in the FOLFOX regimen are all FDA (Food and Drug Administration) approved
and have been used routinely to treat patients with advanced colorectal cancer.
radiation, known as 5FUCMT, (the chemotherapy drugs 5-fluorouracil/capecitabine and radiation
therapy) prior to surgery. Although radiation therapy to the pelvis has been a standard and
important part of treatment for rectal cancer and has been shown to decrease the risk of the
cancer coming back in the same area in the pelvis, some patients experience undesirable side
effects from the radiation and there have been important advances in chemotherapy, surgery,
and radiation which may be of benefit. The purpose of this study is to compare the effects,
both good and bad, of the standard treatment of chemotherapy and radiation to chemotherapy
using a combination regimen known as FOLFOX, (the drugs 5-fluorouracil (5-FU), oxaliplatin
and leucovorin) and selective use of the standard treatment, depending on response to the
FOLFOX. The drugs in the FOLFOX regimen are all FDA (Food and Drug Administration) approved
and have been used routinely to treat patients with advanced colorectal cancer.
OUTLINE: This is a multicenter, phase II/III study. Patients are stratified according to ECOG
performance status (0 or 1 vs 2) and randomized to 1 of 2 treatment regimens. Patients will
receive full supportive care while on this study.
OBJECTIVES:
Primary
1. Phase II component: To assure that neoadjuvant FOLFOX followed by selective use of
5FUCMT group (Group 1) maintains the current high rate of pelvic R0 resection and is
consistent with non-inferiority for time to local recurrence (TLR).
2. Phase III component: To compare neoadjuvant FOLFOX followed by selective use of 5FUCMT
(Group 1) to standard 5FUCMT (Group 2) with respect to the co-primary endpoints of the
Time to Local Recurrence (TLR) and Disease-Free Survival (DFS).
Secondary
1. To determine if the neoadjuvant FOLFOX followed by selective use of 5FUCMT (Group 1) is
non-inferior to the standard group 5FUCMT (Group 2) with respect to the proportion of
patients who achieve a pathologic complete response (pCR) at the time of surgical
resection.
2. To determine if the neoadjuvant FOLFOX followed by selective use of 5FUCMT (Group 1) is
non-inferior to the standard 5FUCMT (Group 2) with respect to overall survival.
3. To evaluate and compare the adverse event profile and surgery complications between two
groups.
4. To estimate the proportion of patients in the selective group (Group 1) who receive: 1)
pre-operative 5FUCMT; 2) post-operative 5FUCMT; 3) either pre- or post-operative 5FUCMT.
Event monitoring of patients will continue up to 8 years post randomization.
performance status (0 or 1 vs 2) and randomized to 1 of 2 treatment regimens. Patients will
receive full supportive care while on this study.
OBJECTIVES:
Primary
1. Phase II component: To assure that neoadjuvant FOLFOX followed by selective use of
5FUCMT group (Group 1) maintains the current high rate of pelvic R0 resection and is
consistent with non-inferiority for time to local recurrence (TLR).
2. Phase III component: To compare neoadjuvant FOLFOX followed by selective use of 5FUCMT
(Group 1) to standard 5FUCMT (Group 2) with respect to the co-primary endpoints of the
Time to Local Recurrence (TLR) and Disease-Free Survival (DFS).
Secondary
1. To determine if the neoadjuvant FOLFOX followed by selective use of 5FUCMT (Group 1) is
non-inferior to the standard group 5FUCMT (Group 2) with respect to the proportion of
patients who achieve a pathologic complete response (pCR) at the time of surgical
resection.
2. To determine if the neoadjuvant FOLFOX followed by selective use of 5FUCMT (Group 1) is
non-inferior to the standard 5FUCMT (Group 2) with respect to overall survival.
3. To evaluate and compare the adverse event profile and surgery complications between two
groups.
4. To estimate the proportion of patients in the selective group (Group 1) who receive: 1)
pre-operative 5FUCMT; 2) post-operative 5FUCMT; 3) either pre- or post-operative 5FUCMT.
Event monitoring of patients will continue up to 8 years post randomization.
Registration Inclusion Criteria:
1. Age ≥ 18 years at diagnosis
2. Diagnosis of rectal adenocarcinoma
3. Radiologically measurable or clinically evaluable disease as defined in the protocol
4. ECOG Performance Status (PS): 0, 1 or 2
5. For this patient, the standard treatment recommendation in the absence of a clinical
trial would be combined modality neoadjuvant chemoradiation followed by curative
intent surgical resection
6. Candidate for sphincter-sparing surgical resection prior to neoadjuvant therapy
according to the primary surgeon
7. Primary surgeon is credentialed or is willing to be credentialed in Total Mesorectal
Excision (TME), which entails submission of photos of a single TME specimen either
before enrolling the first patient or by using the surgeon's 1st accrued case.
8. Clinical Stage: T2N1, T3N0, T3N1.
- N2 disease is to be estimated as four or more lymph nodes that are ≥ 10 mm.
- Clinical staging should be estimated based on the combination of the following
assessments: physical exam by the primary surgeon, CT or PET/CT scan of the
chest/abdomen/pelvis and either a pelvic MRI or an ultrasound (ERUS). If a pelvic
MRI is peformed, it is acceptable to perform CT of the chest/abdomen, ommitting
CT imaging of the pelvis.
9. The following laboratory values obtained ≤ 28 days prior to registration:
- Absolute neutrophil count (ANC) ≥ 1500/mm^3
- Platelet count ≥ 100,000/mm^3
- Hemoglobin > 8.0 g/dL
- Total bilirubin ≤ 1.5 x upper limit of normal (ULN)
- SGOT (AST) ≤ 3 x ULN
- SGPT (ALT) ≤ 3 x ULN
- Creatinine ≤1.5 x ULN
10. Negative pregnancy test done ≤ 7 days prior to registration, for women of childbearing
potential only
11. Patient of child-bearing potential is willing to employ adequate contraception
12. Provide informed written consent
13. Willing to return to enrolling medical site for all study assessments
Registration Exclusion Criteria:
1. Clinical T4 tumors
2. Primary surgeon indicates need for abdominoperineal (APR) at baseline
3. Evidence that the tumor is adherent to or invading the mesorectal fascia on imaging
studies such that the surgeon would not be able to perform an R0 resection (one with
negative margins)
4. Tumor is causing symptomatic bowel obstruction (patients who have had a temporary
diverting ostomy are eligible).
5. Chemotherapy within 5 years prior to registration. Hormonal therapy is allowable if
the disease free interval is ≥ 5 years.
6. Any prior pelvic radiation
7. Other invasive malignancy ≤ 5 years prior to registration. Exceptions are colonic
polyps, non-melanoma skin cancer, ductal carcinoma in situ, bladder carcinoma in situ,
or carcinoma-in-situ of the cervix.
8. Any of the following because this study involves an agent that has known genotoxic,
mutagenic and teratogenic effects.
- Pregnant women
- Nursing women
- Men or women of childbearing potential who are unwilling to employ adequate
contraception
9. Co-morbid illnesses or other concurrent disease which, in the judgment of the
clinician obtaining informed consent, would make the patient inappropriate for entry
into this study or interfere significantly with the proper assessment of safety and
toxicity of the prescribed regimens.
We found this trial at
1060
sites
Lexington, Kentucky 40504
Principal Investigator: Mehmet S. Copur
Phone: 308-398-6518
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1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
Albuquerque, New Mexico 87131
(505) 272-4946
![University of New Mexico Cancer Center](/wp-content/uploads/logos/university-of-new-mexico-cancer-center.jpg)
Principal Investigator: Ashwani Rajput
Phone: 505-925-0366
University of New Mexico Cancer Center It’s been 40 years since the New Mexico State...
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2545 Schoenersville Rd
Bethlehem, Pennsylvania 18017
Bethlehem, Pennsylvania 18017
(484) 884-2200
![Lehigh Valley Hospital - Muhlenberg](/wp-content/uploads/logos/lehigh-valley-hospital---muhlenberg.png)
Principal Investigator: Christopher M. Reynolds
Phone: 734-712-3671
Lehigh Valley Hospital - Muhlenberg At Lehigh Valley Health Network, we continually go the extra...
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75 Francis street
Boston, Massachusetts 02115
Boston, Massachusetts 02115
(617) 732-5500
![Brigham and Women's Hosp](/wp-content/uploads/logos/brigham-and-women-s-hosp.jpg)
Principal Investigator: Deborah Schrag
Phone: 773-702-9171
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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330 Brookline Ave
Boston, Massachusetts 02215
Boston, Massachusetts 02215
617-667-7000
![Beth Israel Deaconess Medical Center](/wp-content/uploads/logos/beth-israel-deaconess-medical-center.jpg)
Principal Investigator: Deborah Schrag
Phone: 617-667-9925
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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Bremerton, Washington 98310
Principal Investigator: Mehmet S. Copur
Phone: 308-398-6518
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666 Elm Street
Buffalo, New York 14263
Buffalo, New York 14263
(716) 845-2300
![Roswell Park Cancer Institute](/wp-content/uploads/logos/roswell-park-cancer-institute.jpg)
Principal Investigator: Steven Nurkin
Phone: 877-275-7724
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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1 South Prospect Street
Burlington, Vermont 05401
Burlington, Vermont 05401
802-656-8990
Principal Investigator: Steven Ades
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1300 Jefferson Park Avenue
Charlottesville, Virginia 22908
Charlottesville, Virginia 22908
434-243-6784
![University of Virginia Cancer Center](/wp-content/uploads/logos/university-of-virginia-cancer-center.jpg)
Principal Investigator: Traci L. Hedrick
Phone: 434-243-6303
University of Virginia Cancer Center We are fortunate in having state of the art clinical...
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1300 Jefferson Park Avenue
Charlottesville, Virginia 22908
Charlottesville, Virginia 22908
434-243-6784
![University of Virginia Cancer Center](/wp-content/uploads/logos/university-of-virginia-cancer-center.jpg)
University of Virginia Cancer Center We are fortunate in having state of the art clinical...
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3500 Gaston Avenue
Dallas, Texas 75246
Dallas, Texas 75246
1.800.422.9567
![Baylor University Medical Center](/wp-content/uploads/logos/baylor-university-medical-center.jpg)
Principal Investigator: James W. Fleshman
Phone: 800-422-9567
Baylor University Medical Center Baylor University Medical Center in Dallas, TX is ranked nationally in...
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3300 Gallows Road
Falls Church, Virginia 22042
Falls Church, Virginia 22042
(703) 776-4001
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Principal Investigator: Timothy L. Cannon
Phone: 703-208-6650
Inova Fairfax Hospital Inova Fairfax Hospital, Inova's flagship hospital, is an 833-bed, nationally recognized regional...
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1 Hurley Plaza
Flint, Michigan 48503
Flint, Michigan 48503
(810) 262-9000
![Hurley Medical Center](/wp-content/uploads/logos/hurley-medical-center.png)
Principal Investigator: Christopher M. Reynolds
Phone: 734-712-3671
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
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4725 North Federal Highway
Fort Lauderdale, Florida 33308
Fort Lauderdale, Florida 33308
(954) 771-8000
![Holy Cross Hospital](/wp-content/uploads/logos/holy-cross-hospital.jpg)
Principal Investigator: Michael A. Schwartz
Phone: 954-267-7750
Holy Cross Hospital While spirituality plays an essential role in the way that we minister...
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200 North Park Street
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
(269) 382-2500
![West Michigan Cancer Center](/wp-content/uploads/logos/west-michigan-cancer-center.png)
Principal Investigator: Kathleen J. Yost
Phone: 616-391-1230
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
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Bronson Methodist Hospital Our healthcare system serves patients and families throughout southwest Michigan and northern...
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1800 West Charleston Boulevard
Las Vegas, Nevada 89102
Las Vegas, Nevada 89102
(702) 383-2000
![University Medical Center of Southern Nevada](/wp-content/uploads/logos/university-medical-center-of-southern-nevada.jpg)
Principal Investigator: John A. Ellerton
Phone: 702-384-0013
University Medical Center of Southern Nevada University Medical Center is dedicated to providing the highest...
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8700 Beverly Blvd # 8211
Los Angeles, California 90048
Los Angeles, California 90048
(1-800-233-2771)
![Cedars-Sinai Medical Center](/wp-content/uploads/logos/cedars-sinai-med-ctr.png)
Principal Investigator: Richard Tuli
Phone: 310-423-8965
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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300 Community Drive
Manhasset, New York 11030
Manhasset, New York 11030
(516) 562-0100
![North Shore University Hospital](/wp-content/uploads/logos/north-shore-university-hospital.jpg)
Principal Investigator: Tony Philip
Phone: 516-734-8954
North Shore University Hospital North Shore-LIJ Health System includes 16 award-winning hospitals and nearly 400...
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4805 Northeast Glisan Street
Portland, Oregon 97213
Portland, Oregon 97213
(503) 215-1111
![Providence Portland Medical Center](/wp-content/uploads/logos/providence-portland-medical-center.png)
Principal Investigator: Alison K. Conlin
Phone: 503-215-2614
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
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401 College Street
Richmond, Virginia 23298
Richmond, Virginia 23298
(804) 828-0450
![Virginia Commonwealth University Massey Cancer Center](/wp-content/uploads/logos/virginia-commonwealth-university-massey-cancer-center.jpg)
Virginia Commonwealth University Massey Cancer Center Founded in 1974, VCU Massey Cancer Center is a...
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60 Crittenden Blvd # 70
Rochester, New York 14642
Rochester, New York 14642
(585) 275-2121
![University of Rochester](/wp-content/uploads/logos/university-of-rochester.png)
Principal Investigator: Paul M. Barr
Phone: 585-275-5830
University of Rochester The University of Rochester is one of the country's top-tier research universities....
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34800 Bob Wilson Dr,
San Diego, California 92134
San Diego, California 92134
(619) 532-6400
![Naval Medical Center - San Diego](/wp-content/uploads/logos/naval-medical-center---san-diego.png)
Principal Investigator: Preston S. Gable
Phone: 619-532-8712
Naval Medical Center - San Diego We are the largest and most comprehensive military healthcare...
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825 Eastlake Ave E
Seattle, Washington 98109
Seattle, Washington 98109
(206) 288-7222
![Seattle Cancer Care Alliance](/wp-content/uploads/logos/seattle-cancer-care-alliance.jpg)
Principal Investigator: Elena G. Chiorean
Phone: 800-804-8824
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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Seattle, Washington 98104
Principal Investigator: Alison K. Conlin
Phone: 206-215-3086
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1100 Fairview Avenue North
Seattle, Washington 98109
Seattle, Washington 98109
(206) 667-5000
![Fred Hutchinson Cancer Research Center](/wp-content/uploads/logos/fred-hutchinson-cancer-research-center.gif)
Principal Investigator: Elena G. Chiorean
Phone: 800-804-8824
Fred Hutchinson Cancer Research Center At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of...
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3900 W Avera Drive
Sioux Falls, South Dakota 57108
Sioux Falls, South Dakota 57108
(605) 322-4700
![Avera Cancer Institute](/wp-content/uploads/logos/avera-cancer-institute.jpg)
Principal Investigator: Luis A. Rojas-Espaillat
Phone: 888-634-7268
Avera Cancer Institute Avera, the health ministry of the Benedictine and Presentation Sisters, is a...
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601 South Sherman Street
Spokane, Washington 99202
Spokane, Washington 99202
(509) 228-1000
![Cancer Care Northwest - Spokane South](/wp-content/uploads/logos/cancer-care-northwest---spokane-south.jpg)
Principal Investigator: Elena G. Chiorean
Phone: 509-228-1680
Cancer Care Northwest - Spokane South Cancer Care Northwest is the Inland Northwest’s premier cancer...
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Tampa General Hospital In a diverse city known for its rich culture and beautiful beaches,...
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808 North 39th Avenue
Yakima, Washington 98902
Yakima, Washington 98902
Principal Investigator: John A. Keech
Phone: 509-574-3535
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'Aiea, Hawaii 96701
Principal Investigator: Jeffrey L. Berenberg
Phone: 808-524-6115
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98-1079 Moanalua Road
'Aiea, Hawaii 96701
'Aiea, Hawaii 96701
Principal Investigator: Jeffrey L. Berenberg
Phone: 808-524-6115
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Aberdeen, Washington 98520
Principal Investigator: Alison K. Conlin
Phone: 360-412-8958
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1200 Old York Road
Abington, Pennsylvania 19001
Abington, Pennsylvania 19001
(215) 481–2000
![Abington Memorial Hospital](/wp-content/uploads/logos/abington-memorial-hospital.jpg)
Principal Investigator: Willard G. Andrews
Phone: 215-481-2402
Abington Memorial Hospital Abington Memorial Hospital (AMH) is a 665-bed, regional referral center and teaching...
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Akron, Ohio 44304
Principal Investigator: Desiree E. Doncals
Phone: 330-375-6101
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Allentown, Pennsylvania 18103
Principal Investigator: Christopher M. Reynolds
Phone: 734-712-3671
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Altamonte Springs, Florida 32701
Principal Investigator: Carlos A. Alemany
Phone: 773-702-9171
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Amarillo, Texas 79106
Principal Investigator: Suhasini (Sue) Nadesan
Phone: 806-212-1985
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170 North 1100 East
American Fork, Utah 84003
American Fork, Utah 84003
Principal Investigator: R. J. Lee
Phone: 801-855-4100
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Anaconda, Montana 59711
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
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Anacortes, Washington 98221
Principal Investigator: Alison K. Conlin
Phone: 503-215-2614
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Anaheim, California 92806
Principal Investigator: Gary L. Buchschacher
Phone: 800-398-3996
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Anchorage, Alaska 99508
Principal Investigator: Alison K. Conlin
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Alison K. Conlin
Phone: 773-702-9171
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Anchorage, Alaska 99508
Principal Investigator: Alison K. Conlin
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Alison K. Conlin
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Alison K. Conlin
Phone: 907-212-6871
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Anchorage, Alaska 98508
Principal Investigator: Alison K. Conlin
Phone: 907-212-6871
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Anchorage, Alaska 99504
Principal Investigator: Alison K. Conlin
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Alison K. Conlin
Phone: 907-212-6871
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5301 McAuley Drive
Ann Arbor, Michigan 48197
Ann Arbor, Michigan 48197
734-712-3456
![Saint Joseph Mercy Hospital](/wp-content/uploads/logos/saint-joseph-mercy-hospital.jpg)
Principal Investigator: Christopher M. Reynolds
Phone: 734-712-3671
Saint Joseph Mercy Hospital St. Joseph Mercy Ann Arbor Hospital is a 537-bed teaching hospital...
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1500 East Medical Center Drive
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
800-865-1125
![University of Michigan Comprehensive Cancer Center](/wp-content/uploads/logos/university-of-michigan-comprehensive-cancer-center.jpg)
Principal Investigator: John C. Krauss
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
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Antigo, Wisconsin 54409
Principal Investigator: Harish G. Ahuja
Phone: 715-623-9869
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Antioch, California 94531
Principal Investigator: Tatjana Kolevska
Phone: 877-642-4691
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921 North Oak Park Boulevard
Arroyo Grande, California 93420
Arroyo Grande, California 93420
Principal Investigator: John A. Ellerton
Phone: 702-384-0013
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550 Peachtree St NE
Atlanta, Georgia 30308
Atlanta, Georgia 30308
(404) 686-4411
![Emory University Hospital Midtown](/wp-content/uploads/logos/emory-university-hospital-midtown.png)
Principal Investigator: Patrick S. Sullivan
Phone: 888-946-7447
Emory University Hospital Midtown Emory University Hospital Midtown is a 511-bed community-based, acute care teaching...
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Atlanta, Georgia 30322
Principal Investigator: Patrick S. Sullivan
Phone: 404-778-1868
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Atlanta, Georgia 30342
Principal Investigator: Patrick S. Sullivan
Phone: 888-823-5923
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Auburn, California 95603
Principal Investigator: Oleg I. Krijanovski
Phone: 415-209-2686
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Auburn, California 95602
Principal Investigator: Oleg I. Krijanovski
Phone: 415-209-2686
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Auburn, New York 13021
Principal Investigator: Jeffrey J. Kirshner
Phone: 315-472-7504
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Auburn, Washington 98001
Principal Investigator: John A. Keech
Phone: 253-887-9333
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Aurora, Colorado 80012
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
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Medical Center of Aurora At The Medical Center of Aurora and Centennial Medical Plaza patients...
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12605 East 16th Avenue
Aurora, Colorado 80045
Aurora, Colorado 80045
720-848-0000
![University of Colorado Hospital](/wp-content/uploads/logos/university-of-colorado-hospital-site.jpg)
Principal Investigator: Tracey E. Schefter
Phone: 720-848-0650
University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...
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2000 Ogden Ave
Aurora, Illinois 60504
Aurora, Illinois 60504
(630) 978-6200
![Rush - Copley Medical Center](/wp-content/uploads/logos/rush---copley-medical-center.png)
Principal Investigator: Yujie Zhao
Phone: 630-978-6212
Rush - Copley Medical Center Rush-Copley is proud to be the leading provider of health...
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1500 Red River Street
Austin, Texas 78701
Austin, Texas 78701
Principal Investigator: Om N. Pandey
Phone: 512-324-7991
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Aventura, Florida 33180
Principal Investigator: Michael A. Schwartz
Phone: 773-702-9171
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Bainbridge Island, Washington 98110
Principal Investigator: John A. Keech
Phone: 206-342-6954
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3325 Pocahontas Road
Baker City, Oregon 97814
Baker City, Oregon 97814
Principal Investigator: Christopher M. Reynolds
Phone: 734-712-3671
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Baldwin Park, California 91706
Principal Investigator: Jonathan A. Polikoff
Phone: 626-564-3455
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401 North Broadway
Baltimore, Maryland 21287
Baltimore, Maryland 21287
410-955-5000
![Johns Hopkins University-Sidney Kimmel Cancer Center](/wp-content/uploads/logos/johns-hopkins-university-sidney-kimmel-cancer-center.png)
Johns Hopkins University-Sidney Kimmel Cancer Center The name Johns Hopkins has become synonymous with excellence...
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22 South Greene Street
Baltimore, Maryland 21201
Baltimore, Maryland 21201
410-328-7904
![University of Maryland Greenebaum Cancer Center](/wp-content/uploads/logos/university-of-maryland-greenebaum-cancer-center.jpg)
University of Maryland Greenebaum Cancer Center The University of Maryland Marlene and Stewart Greenebaum Cancer...
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Sinai Hospital of Baltimore Sinai Hospital of Baltimore provides a broad array of high-quality, cost-effective...
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Baltimore, Maryland 21218
Principal Investigator: John L. Marshall
Phone: 410-261-8151
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Baltimore, Maryland 21239
Principal Investigator: John L. Marshall
Phone: 410-261-8151
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489 State St
Bangor, Maine 04401
Bangor, Maine 04401
(207) 973-7000
![Eastern Maine Medical Center](/wp-content/uploads/logos/eastern-maine-medical-center.png)
Principal Investigator: Thomas H. Openshaw
Phone: 207-973-4274
Eastern Maine Medical Center Located in Bangor, Eastern Maine Medical Center (EMMC) serves communities throughout...
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Summa Barberton Hospital Summa Barberton Hospital is a full member of Summa Health System and...
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4305 New Shepherdsville Road
Bardstown, Kentucky 40004
Bardstown, Kentucky 40004
Principal Investigator: Mehmet S. Copur
Phone: 308-398-6518
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Basking Ridge, New Jersey 07920
Principal Investigator: Leonard B. Saltz
Phone: 212-639-7592
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Baton Rouge, Louisiana 70805
Principal Investigator: Augusto C. Ochoa
Phone: 225-215-1353
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Baton Rouge, Louisiana 70809
Principal Investigator: Augusto C. Ochoa
Phone: 225-215-1353
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Baton Rouge, Louisiana 70809
Principal Investigator: Augusto C. Ochoa
Phone: 225-215-1353
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4950 Essen Lane
Baton Rouge, Louisiana 70809
Baton Rouge, Louisiana 70809
Principal Investigator: Augusto C. Ochoa
Phone: 225-215-1353
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Bay Shore, New York 11706
Principal Investigator: Tony Philip
Phone: 516-734-8954
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3535 Pentagon Boulevard
Beavercreek, Ohio 45431
Beavercreek, Ohio 45431
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
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2500 Bellevue Medical Center Drive
Bellevue, Nebraska 68123
Bellevue, Nebraska 68123
Principal Investigator: Jean L. Grem
Phone: 402-559-6941
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Bellevue, Washington 98004
Principal Investigator: John A. Keech
Phone: 425-688-5407
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Bellflower, California 90706
Principal Investigator: Jonathan A. Polikoff
Phone: 626-564-3455
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800 Farson Street
Belpre, Ohio 45714
Belpre, Ohio 45714
(740) 401-0417
![Strecker Cancer Center-Belpre](/wp-content/uploads/logos/strecker-cancer-center-belpre.jpg)
Principal Investigator: Timothy D. Moore
Phone: 800-523-3977
Strecker Cancer Center-Belpre The Memorial Health System's Strecker Cancer Center, Belpre combines the clinical expertise...
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Bend, Oregon 97701
Principal Investigator: Alison K. Conlin
Phone: 541-706-2909
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