Nebulized Magnesium Sulfate in Children With Moderate to Severe Asthma Exacerbation

Patients presenting to the Emergency Department for acute asthma exacerbation will receive
standard care of up to three doses of albuterol and ipratropium bromide plus oral steroid
medication. Those seven years of age and older who require further treatment will be screened
for eligibility. Eligibility screening will comprise measurement of forced expiratory volume
in one second (FEV1) with a bedside spirometer by a respiratory therapist. Children under the
age of seven are generally unable to complete spirometry maneuvers and will thus be excluded.
The Pediatric Asthma Severity Score (PASS) will also be noted by a respiratory therapist.
Patients able to complete spirometry testing and with an FEV1 less than 70% of predicted (the
definition of moderate asthma exacerbation) will be enrolled. Enrolled patients will be
randomized to receive either Children's Medical Center standard care of 15 mg albuterol
diluted in 22 ml of normal saline or the study intervention of 15 mg of albuterol diluted in
22 ml of magnesium sulfate solution. This solution will be prepared at the time of use by a
pharmacist in the Emergency Department and will consist of 22 ml of a commercially available
40 mg/ml magnesium sulfate solution (880 mg). The nebulizer treatment will be given over
approximately one hour via a large volume nebulizer at 25 ml/hr. Physicians, nurses, and
respiratory therapists will be blinded to the diluent used. Vital signs will be noted at
baseline. Heart rate, heart rhythm, respiratory rate, and pulse oximetry will be monitored
continuously while blood pressure will be measured at baseline and every 15 minutes during
study medication administration. The study physician, treating physician, and/or bedside
nurse will monitor these values for any clinically significant changes. At the end of the 15
mg albuterol treatment FEV1 and PASS will again be noted. Any further treatments needed, as
determined by the treating physician, will be given following Children's Medical Center
standard of care. At the discretion of the treating physician intravenous magnesium sulfate
may be used post study intervention. The dose used for study participants will be the
Children's Medical Center standard dose of 75 mg/kg (max 3 g) minus 880 mg to avoid the risk
of magnesium sulfate overdose. Further treatments and patient disposition will be observed by
study personnel and noted. Bounce-back rates will be collected by review of enrolled
patients' medical record.

Inclusion Criteria:

- Patients age ≥ seven years

- Previous diagnosis of asthma or previous episode of wheezing treated with beta-agonist
medication

- Able to complete bedside spirometry

- FEV1 < 70% predicted

Exclusion Criteria:

- Known allergy to magnesium sulfate

- Known contra-indication to albuterol

- Respiratory distress occurring as a result of bedside spirometry

- History of neuromuscular disease, cardiac disease, renal disease, or underlying
chronic lung disease

- Pregnancy

- Use of oral steroid medication within 72 hours of presentation

- Radiographic evidence of pneumonia at presentation

- Intubation during the current encounter prior to study enrollment

- Administration of intravenous magnesium sulfate prior to study enrollment

- Prior participation in this study