A Study of Dalcetrapib in Patients With Stable Coronary Heart Disease, With Coronary Heart Disease Risk Equivalents or at Elevated Risk for Cardiovascular Disease



Status:Completed
Conditions:High Cholesterol, Peripheral Vascular Disease, Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:45 - Any
Updated:8/3/2016
Start Date:January 2012
End Date:July 2012

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 3b, Multi-Center, Double-Blind, Placebo-Controlled, Parallel Group, Study to Evaluate the Effect of Dalcetrapib 600 mg on Cardiovascular (CV) Events in Adult Patients With Stable Coronary Heart Disease (CHD), CHD Risk Equivalents or at Elevated Risk for Cardiovascular Disease (CVD).

This multicenter, randomized, double-blind, placebo-controlled, parallel-group study will
evaluate the potential of dalcetrapib to reduce cardiovascular morbidity and mortality in
patients with stable coronary heart disease (CHD), with CHD risk equivalents or at elevated
risk for cardiovascular disease. Eligible patients will be randomized to receive either
dalcetrapib 600 mg orally daily or placebo orally daily, on a background of contemporary,
guidelines-based medical care. Anticipated time on study treatment is 4 years.


Inclusion Criteria:

- Adult patients, >/= 45 years of age

- Established cardiovascular disease A stable coronary disease B cerebrovascular
disease C peripheral artery disease

- Without established coronary disease D pharmacologically treated type 2 diabetes
mellitus and one or more risk factor(s) for cardiovascular disease E 3 or more risk
factors for cardiovascular disease

- Receiving evidence-based medical and dietary management of dyslipidemia

Exclusion Criteria:

- Occurrence of myocardial infarction, hospitalization for unstable angina, stroke or
revascularization (coronary, carotid or peripheral) within three months prior to
randomization

- Uncontrolled hypertension

- Uncontrolled diabetes

- Concomitant treatment with any other drug raising HDL-C

- Previous treatment with compounds targeting cholesteryl ester transfer protein (CETP)
We found this trial at
116
sites
Clinical Trial Facility in Tallahassee Florida
Tallahassee, Florida
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Clinical Trial Facility in Albany New York
Albany, New York 12205
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Clinical Trial Facility in Alexandria Louisiana
Alexandria, Louisiana 71301
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Clinical Trial Facility in Allentowm Pennsylvania
Allentowm, Pennsylvania 18105
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Clinical Trial Facility in Altoona Pennsylvania
Altoona, Pennsylvania 16602
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Clinical Trial Facility in Anaheim California
Anaheim, California 92801
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Clinical Trial Facility in Anderson South Carolina
Anderson, South Carolina
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Clinical Trial Facility in Asheville North Carolina
Asheville, North Carolina
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Clinical Trial Facility in Atlanta Georgia
Atlanta, Georgia
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Clinical Trial Facility in Aurora Illinois
Aurora, Illinois 60506
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Clinical Trial Facility in Bangor Maine
Bangor, Maine 04402
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Clinical Trial Facility in Beltsville Maryland
Beltsville, Maryland
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Clinical Trial Facility in Birmingham Alabama
Birmingham, Alabama
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Clinical Trial Facility in Boston Massachusetts
Boston, Massachusetts
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Clinical Trial Facility in Boynton Beach Florida
Boynton Beach, Florida 33472
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Clinical Trial Facility in Bridgeport Connecticut
Bridgeport, Connecticut
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Clinical Trial Facility in Bronx New York
Bronx, New York
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Clinical Trial Facility in Buffalo New York
Buffalo, New York
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Clinical Trial Facility in Camden New Jersey
Camden, New Jersey 08103
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Clinical Trial Facility in Camp Hill Pennsylvania
Camp Hill, Pennsylvania 17011
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Clinical Trial Facility in Charlottesville Virginia
Charlottesville, Virginia
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Clinical Trial Facility in Chesterfield Missouri
Chesterfield, Missouri
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Clinical Trial Facility in Cincinnati Ohio
Cincinnati, Ohio
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Clinical Trial Facility in Cleveland Ohio
Cleveland, Ohio
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Clinical Trial Facility in Colorado Springs Colorado
Colorado Springs, Colorado 80910
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Clinical Trial Facility in Columbia Missouri
Columbia, Missouri 65201
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Clinical Trial Facility in Cortlandt Manor New York
Cortlandt Manor, New York 10567
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Clinical Trial Facility in Covington Georgia
Covington, Georgia 30015
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Clinical Trial Facility in Cumming Georgia
Cumming, Georgia 30041
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Clinical Trial Facility in Dallas Texas
Dallas, Texas 75390
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Clinical Trial Facility in Danville Virginia
Danville, Virginia 24541
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Clinical Trial Facility in Daytona Beach Florida
Daytona Beach, Florida 32117
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Clinical Trial Facility in Decatur Georgia
Decatur, Georgia 30033
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Clinical Trial Facility in Denver Colorado
Denver, Colorado
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Clinical Trial Facility in Doylestown Pennsylvania
Doylestown, Pennsylvania 18901
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Clinical Trial Facility in Durham North Carolina
Durham, North Carolina
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Clinical Trial Facility in Elizabeth City North Carolina
Elizabeth City, North Carolina 27909
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Clinical Trial Facility in Elkhart Indiana
Elkhart, Indiana 46514
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Clinical Trial Facility in Erie Pennsylvania
Erie, Pennsylvania 16502
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Clinical Trial Facility in Fargo North Dakota
Fargo, North Dakota 58122
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Clinical Trial Facility in Fort Myers Florida
Fort Myers, Florida 33916
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Clinical Trial Facility in Fullerton California
Fullerton, California 92835
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Clinical Trial Facility in Greer South Carolina
Greer, South Carolina 29650
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Clinical Trial Facility in Haddon Heights New Jersey
Haddon Heights, New Jersey 08035
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Clinical Trial Facility in Hammond Indiana
Hammond, Indiana 46320
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Clinical Trial Facility in Hartford Connecticut
Hartford, Connecticut 06106
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Clinical Trial Facility in Haverhill Massachusetts
Haverhill, Massachusetts
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Clinical Trial Facility in Hickory North Carolina
Hickory, North Carolina 28601
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Clinical Trial Facility in Humble Texas
Humble, Texas 77338
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Clinical Trial Facility in Huntsville Alabama
Huntsville, Alabama 35801
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Clinical Trial Facility in Hyannis Massachusetts
Hyannis, Massachusetts 02601
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Clinical Trial Facility in Indianapolis Indiana
Indianapolis, Indiana 46202
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Clinical Trial Facility in Jackson Michigan
Jackson, Michigan
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Clinical Trial Facility in Jacksonville Florida
Jacksonville, Florida 32209
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Clinical Trial Facility in Johnson City Tennessee
Johnson City, Tennessee 37604
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Clinical Trial Facility in Kalamazoo Michigan
Kalamazoo, Michigan 49048
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Clinical Trial Facility in Kalispell Montana
Kalispell, Montana
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Clinical Trial Facility in Kansas City Missouri
Kansas City, Missouri 64108
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Clinical Trial Facility in Langhorne Pennsylvania
Langhorne, Pennsylvania 19047
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Clinical Trial Facility in Lansdale Pennsylvania
Lansdale, Pennsylvania
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Clinical Trial Facility in Louisville Kentucky
Louisville, Kentucky 40202
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Clinical Trial Facility in Lynchburg Virginia
Lynchburg, Virginia 24501
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Clinical Trial Facility in Manassas Virginia
Manassas, Virginia 20109
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Clinical Trial Facility in Mansfield Ohio
Mansfield, Ohio
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Clinical Trial Facility in Marquette Michigan
Marquette, Michigan
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Clinical Trial Facility in Mentor Ohio
Mentor, Ohio 44060
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Clinical Trial Facility in Midland Michigan
Midland, Michigan 48640
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Clinical Trial Facility in Milton Queensland
Milton, Queensland
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Clinical Trial Facility in Mine Hill New Jersey
Mine Hill, New Jersey
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Clinical Trial Facility in Morehead City North Carolina
Morehead City, North Carolina 28557
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Clinical Trial Facility in Muncie Indiana
Muncie, Indiana
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Clinical Trial Facility in Nashua New Hampshire
Nashua, New Hampshire 03060
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Clinical Trial Facility in North Dartmouth Massachusetts
North Dartmouth, Massachusetts 02747
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Clinical Trial Facility in North Wales Pennsylvania
North Wales, Pennsylvania 19454
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Clinical Trial Facility in Odessa Texas
Odessa, Texas 79761
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Clinical Trial Facility in Overland Park Kansas
Overland Park, Kansas
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Clinical Trial Facility in Panama City Florida
Panama City, Florida 32401
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Clinical Trial Facility in Philadelphia Pennsylvania
Philadelphia, Pennsylvania
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Clinical Trial Facility in Plantation Florida
Plantation, Florida 33317
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Clinical Trial Facility in Port Charlotte Florida
Port Charlotte, Florida 33952
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Clinical Trial Facility in Pottstown Pennsylvania
Pottstown, Pennsylvania 19464
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Clinical Trial Facility in Poughkeepsi New York
Poughkeepsi, New York 12601
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Clinical Trial Facility in Provo Utah
Provo, Utah 86404
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Clinical Trial Facility in Rapid City South Dakota
Rapid City, South Dakota 57701
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Clinical Trial Facility in Richmond Virginia
Richmond, Virginia 23227
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Clinical Trial Facility in Rochester Minnesota
Rochester, Minnesota 55905
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Clinical Trial Facility in Rochester Hills Michigan
Rochester Hills, Michigan 48085
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Clinical Trial Facility in Rock Island Illinois
Rock Island, Illinois 61201
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Clinical Trial Facility in Rocky Mount North Carolina
Rocky Mount, North Carolina
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Clinical Trial Facility in Saginaw Michigan
Saginaw, Michigan 48604
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Clinical Trial Facility in Salisbury Maryland
Salisbury, Maryland 21801
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Clinical Trial Facility in San Diego California
San Diego, California
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Clinical Trial Facility in Santa Ana California
Santa Ana, California 92701
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Clinical Trial Facility in Santa Rosa California
Santa Rosa, California 95405
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Clinical Trial Facility in Saratoga Springs New York
Saratoga Springs, New York 12866
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Clinical Trial Facility in Smithtown New York
Smithtown, New York 11787
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Clinical Trial Facility in South Bend Indiana
South Bend, Indiana 46601
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Clinical Trial Facility in St. Cloud Minnesota
St. Cloud, Minnesota 56303
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Clinical Trial Facility in Statesville North Carolina
Statesville, North Carolina 28677
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Clinical Trial Facility in Syracuse New York
Syracuse, New York 13202
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Clinical Trial Facility in Tampa Florida
Tampa, Florida
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