Naltrexone and Memantine Effects on Alcohol Drinking Behaviors
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 21 - 55 |
| Updated: | 5/18/2017 |
| Start Date: | January 2012 |
| End Date: | May 1, 2017 |
Glutamate-opioid Interactions in Alcohol Drinking Behaviors
The purpose of this study is to evaluate the combined effects of the study medications
naltrexone and memantine on alcohol drinking behaviors. Participants will be randomized to
receive a combination of these medications over a one week period and then participate in a
laboratory session. During this session, participants are given an initial drink of alcohol
followed by the choice to drink up to 12 more drinks over a three-hour period. These
medications are hypothesized to reduce craving and number of drinks consumed prior to and
after exposure to the initial drink of alcohol and during the three hour drinking period.
naltrexone and memantine on alcohol drinking behaviors. Participants will be randomized to
receive a combination of these medications over a one week period and then participate in a
laboratory session. During this session, participants are given an initial drink of alcohol
followed by the choice to drink up to 12 more drinks over a three-hour period. These
medications are hypothesized to reduce craving and number of drinks consumed prior to and
after exposure to the initial drink of alcohol and during the three hour drinking period.
Inclusion Criteria:
- Ages 21-55
- Able to read English at 6th grade level or higher and to complete study evaluations
- Regular alcohol drinker
Exclusion Criteria:
- Individuals who are seeking alcohol treatment
- Medical conditions that would contraindicate the use of study medication
- Regular use of other substances
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