A Study of Changes in Hepatic Function During Radiation Therapy Using Hepatobiliary Single Photon Emission Tomography (SPECT)
| Status: | Completed |
|---|---|
| Conditions: | Liver Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 7/11/2015 |
| Start Date: | August 2008 |
| End Date: | January 2016 |
| Contact: | Mary Feng, MD |
| Phone: | (734) 936-7810 |
A Pilot Study of Changes in Hepatic Function During Radiation Therapy Using Hepatobiliary SPECT
Radiation-induced liver disease (RILD) is a syndrome characterized by the development of
anicteric ascites approximately 2 weeks to 4 months after hepatic irradiation. Previous
studies have shown that both the volume of liver irradiated and the dose of radiation
delivered are prominent factors for development of RILD. While use of a population-based
normal tissue complication probability model allows investigators to limit the risk of RILD
to a clinically acceptable level, a test that permits investigators to determine an
individual's risk of RILD during the course of treatment may allow for individualized
treatment modifications, either to prevent toxicity or increase efficacy.
anicteric ascites approximately 2 weeks to 4 months after hepatic irradiation. Previous
studies have shown that both the volume of liver irradiated and the dose of radiation
delivered are prominent factors for development of RILD. While use of a population-based
normal tissue complication probability model allows investigators to limit the risk of RILD
to a clinically acceptable level, a test that permits investigators to determine an
individual's risk of RILD during the course of treatment may allow for individualized
treatment modifications, either to prevent toxicity or increase efficacy.
Early, but subclinical physiologic changes in the liver may be associated with the future
development of RILD. There are currently limited data on how a local change in hepatic
function associates with regional radiation dose, and how the change of hepatic function
during and after radiation therapy (RT) associates with RILD. In the present study, a
radiological methodology that is minimally invasive will be used to measure volumetric
hepatic functions in patients with intrahepatic malignancies before, during, and after a
course of fractioned radiation therapy.
development of RILD. There are currently limited data on how a local change in hepatic
function associates with regional radiation dose, and how the change of hepatic function
during and after radiation therapy (RT) associates with RILD. In the present study, a
radiological methodology that is minimally invasive will be used to measure volumetric
hepatic functions in patients with intrahepatic malignancies before, during, and after a
course of fractioned radiation therapy.
Inclusion Criteria:
- cancer patients undergoing radiation of the Liver
- women and men who agree to avoid pregnancy
- life expectancy of at least 6 months
Exclusion Criteria:
- pregnant women
- breatsfeeding women
- prisoners
We found this trial at
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site
1500 East Medical Center Drive
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
800-865-1125
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
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