A Study of RoActemra/Actemra (Tocilizumab) Versus Placebo in Patients With Systemic Sclerosis

Inclusion Criteria:

- Adult patients, >/= 18 years of age

- Systemic sclerosis, as defined by American College of Rheumatology (1980) criteria

- Disease duration of manifestation)

- >/= 15 and
- Active disease, as defined by protocol

- Uninvolved skin at injection sites

- Negative pregnancy test for a female subject of childbearing potential

Exclusion Criteria:

- Major surgery (including joint surgery) within 8 weeks prior to and/or during study
enrollment

- Rheumatic autoimmune disease other than systemic sclerosis

- Skin thickening (scleroderma) limited to areas distal to the elbows or knees at
screening

- Previous treatment with tocilizumab

- History of severe allergic or anaphylactic reactions to human, humanized, or murine
monoclonal antibodies

- Severe cardiopulmonary disease

- Known active current or history of recurrent infections

- Use of any investigational, biologic, or immunosuppressive therapies including
intra-articular or parenteral corticosteroids prior to study enrollment as specified
in the protocol

- As specified in the protocol, any current or past medical condition or medical
history involving but not limited to the nervous, renal, pulmonary, endocrine, and
gastrointestinal organ systems determined by the Principal Investigator to pose a
significant safety risk to any subject while participating in the study

- Primary or secondary immunodeficiency