Phase I Safety Trial of Streptococcus Pneumoniae Whole Cell Vaccine (SPWCV) + Alum in Healthy Adults

Inclusion Criteria, Healthy adults:

- If female, not breastfeeding, not pregnant, not planning pregnancy during study
period), and willing to consistently use an adequate method of contraception and have
repeated pregnancy tests.

- In good health with normal laboratory results

- Willing to comply with study restrictions, study schedule, and can be reliably
contacted

Exclusion Criteria:

- Currently consumes alcohol in excess of 2 drinks per day for men or 1 drink per day
for women.

- current use or likely requirement for medications with potential for liver injury or
effect immune system

- History of event or condition such as anaphylaxis, severe allergic reactions, serious
reactions to any vaccines, or other events that might increase risk of reaction to an
investigational disease

- History of diabetes, cancer, autoimmune or immunosuppressive disease or chronic such
as HIV, Hepatitis B or C