Alpha-lipoic Acid/L-acetyl Carnitine for Progressive Supranuclear Palsy
| Status: | Completed |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 40 - 75 |
| Updated: | 10/2/2013 |
| Start Date: | December 2011 |
| End Date: | December 2013 |
| Contact: | Mattson Ogg, BA |
| Email: | mao2026@med.cornell.edu |
| Phone: | 212-746-2474 |
An Open-label Trial of Alpha-lipoic Acid/L-acetyl Carnitine for Progressive Supranuclear Palsy (PSP): Effect Upon Oxidative Damage and Mitochondrial Biomarkers
Studies have shown that alpha-lipoic acid and L-acetyl carnitine may have some
neuroprotective activities and it is hoped that they could be helpful for people with
neurodegenerative illnesses such as progressive supranuclear palsy (PSP).
The purpose of this study is to find out whether the nutritional supplement alpha-lipoic
acid/L-acetyl carnitine is safe and well-tolerated in individuals with PSP when given daily,
and whether it affects their well-being, brain scan measurements and blood tests that
measure the energy metabolism in cells.
Inclusion Criteria:
- Diagnosis of probable PSP by NINDS/PSP workshop criteria (see patient folder)
- Age 40-75 years
- Able to undergo MRI
- Absence of significant medical, psychiatric, and other neurological disease
- Stable intake of supplements and medication
Exclusion Criteria:
- Failure to meet probable PSP diagnosis by NINDS/PSP workshop criteria
- unable to comply with informed consent process
- unable to undergo MRI
- presence of significant medical, psychiatric (incl MDD) or other neurological (incl
epilepsy, brain tumor, stroke) disease
- possibility of pregnancy (negative test required in women of childbearing age)
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Weill Medical College of Cornell University Founded in 1898, and affiliated with what is now...
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