Treatment of Depression Following Multiple Brain Tests
| Status: | Archived |
|---|---|
| Conditions: | Depression, Major Depression Disorder (MDD), Endocrine |
| Therapuetic Areas: | Endocrinology, Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
Medication Treatment Following Neuropsychologic, Dichotic and f-MRI Tests in Depressed Outpatients With Repeat f-MRI Following Treatment
The main purpose of this study is to correlate brain testing with treatment outcome.
40 medication-free Depressed Patients will receive a battery of neuropsychologic tests,
standard dichotic listening tests, EEG, ERP and an f-MRI while performing a neuropsychologic
test, the Simon. Once testing is completed, patients will be treated in an open treatment
trial of SSRI. Non-responders will then receive Bupropion followed by Tricyclic
Antidepressant if still depressed. While our main purpose is to correlate imaging testing
with other measures of brain functioning, we also intend to see whether f-MRI findings
demonstrate specific brain areas which differ between responders and non-responders. At the
end of SSRI treatment, patients will have a second f-MRI scan to investigate any changes
treatment and/or response may have caused.
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