A Safety and Efficacy Study of HPP404 on Weight Loss in Overweight or Obese Subjects

Inclusion Criteria:

- Body Mass Index (BMI) from 30.0 to 39.9 kg/m2, for subjects with no additional co
morbidities;

- BMI from 27 to 39.9 kg/m2, for subjects with co morbidities (i.e. dyslipidemia
defined as high LDL (≥ 160 mg/dL) or high total cholesterol (≥ 240 mg/dL), or
subjects with hypertension)

Exclusion Criteria:

- Systolic blood pressure > 160 mmHg and/or diastolic pressure > 90 mmHg at the
Screening Visit without treatment

- History of use of tobacco or nicotine-containing products 180 days prior to Screening
visit

- Subjects with type 2 diabetes or fasting blood glucose concentration ≥ 126 mg/dL

- History of appetite or weight modifying surgeries/procedures