Cooling to Optimize Organ Life in Donor Study
| Status: | Terminated |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/9/2018 |
| Start Date: | March 2012 |
| End Date: | March 2014 |
Feasibility of Mild-to-moderate Therapeutic Hypothermia as an In-vivo Organ Preservation Strategy in Brain-dead Donors
The purpose of this study is to assess the feasibility and safety of mild-to-moderate
hypothermia as an in-vivo organ preservation strategy compared to normothermia in 60
brain-dead organ donors.
hypothermia as an in-vivo organ preservation strategy compared to normothermia in 60
brain-dead organ donors.
Inclusion Criteria:
- Age greater than 18 years;pronounced dead as per hospital brain-death criteria
- Accepted by organ procurement organization for organ donation
- Subjects within 3 hours of brain death pronouncement
Exclusion Criteria:
- Consent cannot be obtained from authorized representative;mean arterial pressure < 60
mmHg and/ or more than 2 vasopressor and/or inotrope use
- Presence of 2nd or 3rd degree heart block
- Ongoing extracranial hemorrhage
- International normalized ratio > 3.0
- Donors with human-immunodeficiency virus infection
- Pregnancy
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