The Influence of Pressure Pain on [11C]Diprenorphine Binding Potentials
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/11/2012 |
| Start Date: | December 2011 |
| End Date: | December 2013 |
| Contact: | Amanda Cook, M.A. |
| Email: | ahcook@partners.org |
| Phone: | (617) 726-5004 |
Healthy volunteers aged 21 to 50 are needed for a research study investigating whether pain
will alter the binding properties of ([11C]diprenorphine), a molecule that can be used
during brain imaging. Positron Emission Tomography (PET) and functional Magnetic Resonance
(fMRI) imaging will be used in this study.
Inclusion Criteria:
- Healthy male and female adults, 21 to 50 years of age
- No contraindications to fMRI and PET scanning
- Within 15% of ideal body mass index (BMI)
Exclusion Criteria:
- Current significant medical, neurological, or psychiatric illness as assessed by the
Physician Investigators
- Women who are pregnant or breast feeding, have gone through menopause, and/or have
irregular menstrual cycles
- Claustrophobia
- History of head trauma
- Instability of responses to experimental pain (See Study Procedure Section Part II)
- History of asthma
- Use of psychotropic drugs or hormone treatments (including hormonal birth control)
within one year of date of consent
- History of smoking
- Routine exercise in excess of one hour per day and/or three times per week
- Non-fluent English speaker
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