Docetaxel and Cyclophosphamide Compared to Anthracycline-Based Chemotherapy in Treating Women With HER2-Negative Breast Cancer



Status:Active, not recruiting
Conditions:Breast Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:1/11/2019
Start Date:April 2012
End Date:November 2023

Use our guide to learn which trials are right for you!

A Phase III Clinical Trial Comparing the Combination of Docetaxel Plus Cyclophosphamide to Anthracycline-Based Chemotherapy Regimens for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of breast
cancer cells, either by killing the cells or by stopping them from dividing. Giving the drugs
in different combinations may kill more breast cancer cells. Giving combination chemotherapy
after surgery may kill any tumor cells that remain after surgery.

PURPOSE: This randomized phase III trial is studying different combination chemotherapy
regimens and their side effects and comparing how well they work in treating women with
non-metastatic breast cancer.

OBJECTIVES:

Primary

- To determine if the docetaxel and cyclophosphamide (TC) regimen is non-inferior to the
anthracycline-based chemotherapy regimens in terms of invasive disease-free survival
(DFS) by combining B-49 data with the docetaxel, doxorubicin, and cyclophosphamide (TAC)
and TC arms of NSABP B-46-I/US Oncology Research, Inc.(USOR) 07132 and the data from
USOR 06-090.

Secondary

- To determine rates of DFS-ductal carcinoma in situ (DCIS) for the TC and
anthracycline-based chemotherapy regimens.

- To determine rates of overall survival (OS) for the TC and anthracycline-based
chemotherapy regimens.

- To determine rates of recurrence-free interval (RFI) for the TC and anthracycline-based
chemotherapy regimens.

- To evaluate the toxicity associated with each of the regimens.

- To determine the role of TOP2A in prognosis and prediction of degree of benefit from
anthracycline-based chemotherapy over TC. (exploratory)

- To develop predictive markers for benefit from doxorubicin. (exploratory)

OUTLINE: This is a multicenter randomized study. Patients are stratified according to number
of positive nodes (0 vs 1-3 vs 4-9 vs 10+) and hormone-receptor status (estrogen receptor
[ER] and/or progesterone receptor [PgR] positive vs ER and PgR negative). Patients are
randomized to 1 of 2 treatment arms.

Inclusion Criteria:

- The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status
of 0 or 1.

- The tumor must be unilateral invasive adenocarcinoma of the breast on histologic
examination.

- The breast cancer must be Human Epidermal Growth Factor Receptor 2 (HER2)-negative
based on current American Society of Clinical Oncology (ASCO)/CAP Guideline
Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer.
If the result of the in situ hybridization testing (FISH, chromagen in situ
hybridization [CISH], or other) is equivocal, the patient is eligible if there is no
plan to administer HER2-targeted therapy.

- All of the following staging criteria must be met according to American Joint
Committee on Cancer (AJCC) criteria:

- By pathologic evaluation, primary tumor must be pT1-3;

- By pathologic evaluation, ipsilateral nodes must be pN0, pN1 (pN1mi, pN1a, pN1b,
pN1c), pN2a, pN3a, or pN3b.

- If pN0, at least one of the following criteria must be met:

- ER negative and PgR negative; or

- Pathologic tumor size greater than 2.0 cm; or

- T1c (pathologic tumor size greater than 1.0 cm but less than or equal to 2.0 cm)
and ER positive (PgR status may be positive or negative) and either grade 3
histology or Oncotype DX® Recurrence Score of greater than or equal to 25.

- Patients must have undergone either a total mastectomy or breast-conserving surgery
(lumpectomy).

- For patients who undergo lumpectomy, the margins of the resected specimen must be
histologically free of invasive tumor and ductal carcinoma in situ (DCIS) as
determined by the local pathologist. If pathologic examination demonstrates tumor at
the line of resection, additional operative procedures must be performed to obtain
clear margins. If tumor is still present at the resected margin after re-excision(s),
the patient must undergo total mastectomy to be eligible. (Patients with margins
positive for lobular carcinoma in situ [LCIS] are eligible without additional
resection.)

- For patients who undergo mastectomy, margins must be histologically free of invasive
tumor and DCIS.

- Patients must have completed one of the following procedures for evaluation of
pathologic nodal status:

- Sentinel lymphadenectomy alone if pathologic nodal staging based on sentinel
lymphadenectomy is pN0, pN1mi, or pN1b;

- Sentinel lymphadenectomy alone if pathologic nodal staging based on sentinel
lymphadenectomy is pN1a limited to 1 or 2 positive nodes and primary tumor is T1
or T2 by pathologic evaluation;

- Sentinel lymphadenectomy followed by removal of additional non-sentinel lymph
nodes if the sentinel node (SN) is positive; or

- Axillary lymphadenectomy with or without SN isolation procedure.

- The interval between the last surgery for breast cancer (treatment or staging) and
randomization must be no more than 84 days.

- Patients must have ER analysis performed on the primary tumor prior to randomization.
Breast cancer must be assessed for ER status by current ASCO/CAP Guideline
Recommendations for hormone receptor testing. If negative for ER, assessment of PgR
must also be performed according to current ASCO/CAP Guideline Recommendations for
hormone receptor testing. (Either a core biopsy or surgical resection specimen can be
used for ER/PgR testing.)

- The most recent postoperative blood counts, performed within 6 weeks prior to
randomization, must meet the following criteria:

- absolute neutrophil count (ANC) must be greater than or equal to 1200/mm3;

- platelet count must be greater than or equal to 100,000/mm3; and

- hemoglobin must be greater than or equal to 10 g/dL.

- The following criteria for evidence of adequate hepatic function must be met based on
the results of the most recent postoperative tests performed within 6 weeks prior to
randomization:

- total bilirubin must be less than or equal to upper limit of normal (ULN) for the
lab unless the patient has a bilirubin elevation greater than ULN to 1.5 x ULN
due to Gilbert's disease or similar syndrome involving slow conjugation of
bilirubin; and

- alkaline phosphatase must be less than or equal to 2.5 x ULN for the lab; and

- aspartate transaminase (AST) must be less than or equal to 1.5 x ULN for the lab.

- Alkaline phosphatase and AST may not both be greater than the ULN. For example,
if the alkaline phosphatase is greater than the ULN but less than or equal to 2.5
x ULN, then the AST must be less than or equal to the ULN. If the AST is greater
than the ULN but less than or equal to 1.5 x ULN, then the alkaline phosphatase
must be less than or equal to ULN.

- Note: If alanine aminotransferase (ALT) is performed instead of AST (per
institution's standard practice), the ALT value must be less than or equal to 1.5
x ULN; if both were performed, the AST must be less than or equal to 1.5 x ULN.

- Patients with AST or alkaline phosphatase greater than ULN are eligible for inclusion
in the study if liver imaging (CT, MRI, PET-CT, or PET scan performed within 90 days
prior to randomization) does not demonstrate metastatic disease and the requirements
for adequate hepatic function as described above are met.

- Patients with alkaline phosphatase that is greater than ULN but less than or equal to
2.5 x ULN are eligible for inclusion in the study if a bone scan, PET-CT scan, or PET
scan performed within 90 days prior to randomization does not demonstrate metastatic
disease.

- The most recent postoperative serum creatinine performed within 6 weeks prior to
randomization must be less than or equal to ULN for the lab.

- Left ventricular ejection fraction (LVEF) assessment by 2-D echocardiogram or
multigated acquisition (MUGA) scan must be performed within 90 days prior to
randomization. The LVEF must be greater than or equal to 50% regardless of the
facility's lower limit of normal (LLN). (If the facility performing the assessment has
not reported the LVEF as a whole number, decimals reported as greater than or equal to
5 should be rounded up and decimals reported as less than 5 should be rounded down.)

Exclusion criteria:

Patients with one or more of the following conditions are ineligible for this study.

- T4 tumors including inflammatory breast cancer.

- Definitive clinical or radiologic evidence of metastatic disease. (Chest imaging
[mandatory for all patients] and other imaging [if required] must have been performed
within 90 days prior to randomization.)

- Synchronous or previous contralateral invasive breast cancer. (Patients with
synchronous and/or previous contralateral DCIS are eligible.)

- Any history of ipsilateral invasive breast cancer or ipsilateral DCIS.

- History of non-breast malignancies within 5 years prior to randomization, except for
the following: carcinoma in situ of the cervix, colorectal carcinoma in situ, melanoma
in situ, and basal cell and squamous cell carcinomas of the skin.

- Previous therapy with anthracyclines or taxanes for any malignancy.

- Chemotherapy administered for the currently diagnosed breast cancer prior to
randomization.

- Continued endocrine therapy such as raloxifene or tamoxifen (or other SERM) or an
aromatase inhibitor. Patients are eligible if these medications are discontinued prior
to randomization.

- Any sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement
therapy. Patients are eligible if these medications are discontinued prior to
randomization.

- Known active hepatitis B or hepatitis C with abnormal liver function tests.

- Cardiac disease (history of and/or active disease) that would preclude the use of the
drugs included in the treatment regimens. This includes but is not confined to:

- Active cardiac disease

- angina pectoris that requires the use of anti-anginal medication;

- ventricular arrhythmias except for benign premature ventricular contractions;

- supraventricular and nodal arrhythmias requiring a pacemaker or not controlled
with medication;

- conduction abnormality requiring a pacemaker;

- valvular disease with documented compromise in cardiac function;

- symptomatic pericarditis.

- History of cardiac disease

- myocardial infarction documented by elevated cardiac enzymes or persistent
regional wall abnormalities on assessment of left ventricular function;

- history of documented congestive heart failure (CHF);

- documented cardiomyopathy.

- Whole breast radiation therapy (RT) prior to randomization or partial breast RT that
cannot be completed on or before the date of randomization.

- Intrinsic lung disease resulting in dyspnea.

- Unstable diabetes mellitus.

- Active infection or chronic infection requiring suppressive antibiotics.

- History of a major organ allograft or condition requiring chronic immunosuppression,
e.g., kidney, liver, lung, heart, bone marrow transplant, or autoimmune diseases.
(Patients who have received corneal transplants, cadaver skin, or bone transplants are
eligible.)

- Nervous system disorder (paresthesia, peripheral motor neuropathy, or peripheral
sensory neuropathy) greater than or equal to grade 2, per the NCI CTCAE v4.0.

- Conditions that would prohibit administration of corticosteroids.

- Chronic daily treatment with corticosteroids (dose of greater than or equal to 10
mg/day methylprednisolone equivalent) (excluding inhaled steroids).

- History of hypersensitivity reaction to drugs formulated with polysorbate 80.

- Pregnancy or lactation at the time of study entry. (Note: Pregnancy testing must be
performed within 2 weeks prior to randomization according to institutional standards
for women of childbearing potential.)

- Other non-malignant systemic disease that would preclude the patient from receiving
study treatment or would prevent required follow-up.

- Psychiatric or addictive disorders or other conditions that, in the opinion of the
investigator, would preclude the patient from meeting the study requirements.

- Use of any investigational product within 30 days prior to randomization.
We found this trial at
916
sites
820 4th St N
Fargo, North Dakota 58102
(701) 234-6161
Roger Maris Cancer Center Sanford Health is an integrated health system headquartered in the Dakotas...
?
mi
from
Fargo, ND
Click here to add this to my saved trials
361 Old Belgrade Road
Augusta, Maine 04330
(207) 621-6100
Harold Alfond Center for Cancer Care MaineGeneral's Harold Alfond Center for Cancer Care (HACCC) is...
?
mi
from
Augusta, ME
Click here to add this to my saved trials
3400 N Charles St
Baltimore, Maryland 21205
410-516-8000
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
2545 Schoenersville Rd
Bethlehem, Pennsylvania 18017
(484) 884-2200
Lehigh Valley Hospital - Muhlenberg At Lehigh Valley Health Network, we continually go the extra...
?
mi
from
Bethlehem, PA
Click here to add this to my saved trials
800 Washington St
Boston, Massachusetts 02111
(617) 636-5000
Tufts Medical Center Tufts Medical Center is an internationally-respected academic medical center – a teaching...
?
mi
from
Boston, MA
Click here to add this to my saved trials
Bremerton, Washington 98310
?
mi
from
Bremerton, WA
Click here to add this to my saved trials
3550 Jerome Avenue
Bronx, New York 10467
(718) 920-4321
Montefiore Medical Center As the academic medical center and University Hospital for Albert Einstein College...
?
mi
from
Bronx, NY
Click here to add this to my saved trials
666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
?
mi
from
Buffalo, NY
Click here to add this to my saved trials
85 S Prospect St
Burlington, Vermont 5405
(802) 656-3131
University of Vermont The University of Vermont combines faculty-student relationships most commonly found in a...
?
mi
from
Burlington, VT
Click here to add this to my saved trials
1000 Blythe Blvd
Charlotte, North Carolina 28203
(704) 355-2000
?
mi
from
Charlotte, NC
Click here to add this to my saved trials
5050 Anthony Wayne Dr
Detroit, Michigan 48201
(313) 577-2424
Wayne State University Founded in 1868, Wayne State University is a nationally recognized metropolitan research...
?
mi
from
Detroit, MI
Click here to add this to my saved trials
1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
?
mi
from
Flint, MI
Click here to add this to my saved trials
4725 North Federal Highway
Fort Lauderdale, Florida 33308
(954) 771-8000
Holy Cross Hospital While spirituality plays an essential role in the way that we minister...
?
mi
from
Fort Lauderdale, FL
Click here to add this to my saved trials
3 Butternut Drive, Suite B
Greenville, South Carolina 29605
(864) 241-7272
Cancer Centers of the Carolinas - Grove Commons Cancer Centers of the Carolinas is now...
?
mi
from
Greenville, SC
Click here to add this to my saved trials
340 Medical Pkwy
Greer, South Carolina 29650
(864) 334-4900
Cancer Centers of the Carolinas - Greer Medical Oncology Cancer Centers of the Carolinas is...
?
mi
from
Greer, SC
Click here to add this to my saved trials
2500 Campus Rd
Honolulu, Hawaii 96822
(808) 956-8111
Univ of Hawaii Honolulu Community College is an integral part of the University of Hawai?i,...
?
mi
from
Honolulu, HI
Click here to add this to my saved trials
1200 Moursund Street
Houston, Texas 77030
(713) 798-4951
Baylor College of Medicine Baylor College of Medicine in Houston, the only private medical school...
?
mi
from
Houston, TX
Click here to add this to my saved trials
2500 N State St
Jackson, Mississippi 39216
(601) 984-1000
University of Mississippi Medical Center The University of Mississippi Medical Center, located in Jackson, is...
?
mi
from
Jackson, MS
Click here to add this to my saved trials
Jupiter, Florida 33458
?
mi
from
Jupiter, FL
Click here to add this to my saved trials
200 North Park Street
Kalamazoo, Michigan 49007
(269) 382-2500
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
524 South Park Street
Kalamazoo, Michigan 49007
(269) 341-7654
Bronson Methodist Hospital Our healthcare system serves patients and families throughout southwest Michigan and northern...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
701 Doctors Dr
Kinston, North Carolina 28504
(252) 559-2200
Kinston Medical Specialists offers comprehensive medical services for all ages. Whether it’s a case of...
?
mi
from
Kinston, NC
Click here to add this to my saved trials
3525
Lakeland, Florida 33805
?
mi
from
Lakeland, FL
Click here to add this to my saved trials
1800 West Charleston Boulevard
Las Vegas, Nevada 89102
(702) 383-2000
University Medical Center of Southern Nevada University Medical Center is dedicated to providing the highest...
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
8700 Beverly Blvd # 8211
Los Angeles, California 90048
(1-800-233-2771)
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
300 Community Drive
Manhasset, New York 11030
(516) 562-0100
North Shore University Hospital North Shore-LIJ Health System includes 16 award-winning hospitals and nearly 400...
?
mi
from
Manhasset, NY
Click here to add this to my saved trials
1 Gustave L Levy Pl # 271
New York, New York 10029
 (212) 241-6500
Mount Sinai Med Ctr Founded in 1852, The Mount Sinai Hospital is a 1,171-bed, tertiary-care...
?
mi
from
New York, NY
Click here to add this to my saved trials
433 Southwest 10th Street
Ocala, Florida 34471
?
mi
from
Ocala, FL
Click here to add this to my saved trials
4200 Fifth Ave
Pittsburgh, Pennsylvania 15260
(412) 624-4141
University of Pittsburgh The University of Pittsburgh is a state-related research university, founded as the...
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
4805 Northeast Glisan Street
Portland, Oregon 97213
(503) 215-1111
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
?
mi
from
Portland, OR
Click here to add this to my saved trials
593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
?
mi
from
Providence, RI
Click here to add this to my saved trials
60 Crittenden Blvd # 70
Rochester, New York 14642
(585) 275-2121
University of Rochester The University of Rochester is one of the country's top-tier research universities....
?
mi
from
Rochester, NY
Click here to add this to my saved trials
4502 Medical Drive
San Antonio, Texas 78284
(210) 567-7000
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
34800 Bob Wilson Dr,
San Diego, California 92134
(619) 532-6400
Naval Medical Center - San Diego We are the largest and most comprehensive military healthcare...
?
mi
from
San Diego, CA
Click here to add this to my saved trials
100 Campus Dr # 108
Scarborough, Maine 04074
(207) 396-7600
Maine Center for Cancer Medicine and Blood Disorders - Scarborough Maine Center for Cancer Medicine...
?
mi
from
Scarborough, ME
Click here to add this to my saved trials
1100 Fairview Avenue North
Seattle, Washington 98109
206-667-4584
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium The Fred Hutchinson/University of Washington Cancer...
?
mi
from
Seattle, WA
Click here to add this to my saved trials
131 Lila Doyle Drive
Seneca, South Carolina 29672
(864) 888-3717
Cancer Centers of the Carolinas - Seneca Cancer Centers of the Carolinas is now Cancer...
?
mi
from
Seneca, SC
Click here to add this to my saved trials
3900 W Avera Drive
Sioux Falls, South Dakota 57108
(605) 322-4700
Avera Cancer Institute Avera, the health ministry of the Benedictine and Presentation Sisters, is a...
?
mi
from
Sioux Falls, SD
Click here to add this to my saved trials
120 Dillon Dr
Spartanburg, South Carolina 29307
(864) 699-5700
Cancer Centers of the Carolinas - Spartanburg Cancer Centers of the Carolinas is now Cancer...
?
mi
from
Spartanburg, SC
Click here to add this to my saved trials
601 South Sherman Street
Spokane, Washington 99202
(509) 228-1000
Cancer Care Northwest - Spokane South Cancer Care Northwest is the Inland Northwest’s premier cancer...
?
mi
from
Spokane, WA
Click here to add this to my saved trials
820 North Chelan Avenue
Wenatchee, Washington 98801
509) 663-8711
Wenatchee Valley Medical Center Established on July 21, 2013, Confluence Health is an affiliation between...
?
mi
from
Wenatchee, WA
Click here to add this to my saved trials
808 North 39th Avenue
Yakima, Washington 98902
?
mi
from
Yakima, WA
Click here to add this to my saved trials
98-1079 Moanalua Road
'Aiea, Hawaii 96701
?
mi
from
'Aiea, HI
Click here to add this to my saved trials
98-1079 Moanalua Road
'Aiea, Hawaii 96701
?
mi
from
'Aiea, HI
Click here to add this to my saved trials
Aberdeen, South Dakota 57401
?
mi
from
Aberdeen, SD
Click here to add this to my saved trials
Abilene, Texas 79606
?
mi
from
Abilene, TX
Click here to add this to my saved trials
1200 Old York Road
Abington, Pennsylvania 19001
(215) 481–2000
Abington Memorial Hospital Abington Memorial Hospital (AMH) is a 665-bed, regional referral center and teaching...
?
mi
from
Abington, PA
Click here to add this to my saved trials
818 Riverside Ave.
Adrian, Michigan 49221
(517) 265-0900
Bixby Medical Center ProMedica's Mission is to improve your health and well-being. Which is why,...
?
mi
from
Adrian, MI
Click here to add this to my saved trials
Adrian, Michigan 49221
?
mi
from
Adrian, MI
Click here to add this to my saved trials
1 Akron General Ave
Akron, Ohio 44307
(330) 344-6000
Akron General Medical Center It
?
mi
from
Akron, OH
Click here to add this to my saved trials
525 E Market St
Akron, Ohio 44304
(330) 375-3000
Summa Akron City Hospital Summa Akron City Hospital was founded in 1892 to provide a...
?
mi
from
Akron, OH
Click here to add this to my saved trials
?
mi
from
Albany, NY
Click here to add this to my saved trials
?
mi
from
Albany, NY
Click here to add this to my saved trials
Albuquerque, New Mexico 87106
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
Albuquerque, New Mexico 87109
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
Albuquerque, New Mexico 87110
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
Albuquerque, New Mexico 87131
(505) 277-0111
University of New Mexico Founded in 1889 as New Mexico’s flagship institution, the University of...
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
Alexandria, Louisiana 71301
?
mi
from
Alexandria, LA
Click here to add this to my saved trials
1200 S Cedar Crest Blvd
Allentown, Pennsylvania 18103
(610) 402-8000
Lehigh Valley Hospital At Lehigh Valley Health Network, we continually go the extra mile to...
?
mi
from
Allentown, PA
Click here to add this to my saved trials
Amarillo, Texas 79106
?
mi
from
Amarillo, TX
Click here to add this to my saved trials
American Fork, Utah 84003
?
mi
from
American Fork, UT
Click here to add this to my saved trials
Ames, Iowa 50010
McFarland Clinic, PC It has been over 65 years since the founders of McFarland Clinic...
?
mi
from
Ames, IA
Click here to add this to my saved trials
?
mi
from
Amsterdam, NY
Click here to add this to my saved trials
Anacortes, Washington 98221
?
mi
from
Anacortes, WA
Click here to add this to my saved trials
Anaheim, California 92807
?
mi
from
Anaheim, CA
Click here to add this to my saved trials
Anchorage, Alaska 99508
?
mi
from
Anchorage, AK
Click here to add this to my saved trials
Anderson, South Carolina 29621
?
mi
from
Anderson, SC
Click here to add this to my saved trials
2000 E Greenville St
Anderson, South Carolina 29621
(864) 512-4640
AnMedical Health Cancer Center Cancer is the general term for a group of more than...
?
mi
from
Anderson, SC
Click here to add this to my saved trials
Michigan Cancer Research Consortium Community Clinical Oncology Program The Community Clinical Oncology Program (CCOP) is...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
University of Michigan The University of Michigan was founded in 1817 as one of the...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
5301 McAuley Drive
Ann Arbor, Michigan 48197
734-712-3456
Saint Joseph Mercy Hospital St. Joseph Mercy Ann Arbor Hospital is a 537-bed teaching hospital...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Annapolis, Maryland 21401
?
mi
from
Annapolis, MD
Click here to add this to my saved trials
Antigo, Wisconsin 54409
?
mi
from
Antigo, WI
Click here to add this to my saved trials
?
mi
from
Antioch, CA
Click here to add this to my saved trials
Appleton, Wisconsin 54915
?
mi
from
Appleton, WI
Click here to add this to my saved trials
Arlington, Texas 76014
?
mi
from
Arlington, TX
Click here to add this to my saved trials
364 White Oak St
Asheboro, North Carolina 27203
(336) 625-5151
Randolph Hospital Since 1932, Randolph Hospital has been fortunate to employ dedicated and loyal personnel...
?
mi
from
Asheboro, NC
Click here to add this to my saved trials
Asheville, North Carolina 28816
?
mi
from
Asheville, NC
Click here to add this to my saved trials
509 Biltmore Ave
Asheville, North Carolina 28801
(828) 213-1111
Mission Hospitals Mission Hospital, the flagship hospital of Mission Health, has been committed to improving...
?
mi
from
Asheville, NC
Click here to add this to my saved trials
1968 Peachtree Rd NW
Atlanta, Georgia 30309
(404) 605-5000
Piedmont Hospital For more than a century, Piedmont Healthcare has been a recognized leader in...
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Auburn, Washington 98002
?
mi
from
Auburn, WA
Click here to add this to my saved trials
?
mi
from
Augusta, GA
Click here to add this to my saved trials
1501 S Potomac St
Aurora, Colorado 80012
(303) 695-2600
Medical Center of Aurora At The Medical Center of Aurora and Centennial Medical Plaza patients...
?
mi
from
Aurora, CO
Click here to add this to my saved trials
2000 Ogden Ave
Aurora, Illinois 60504
(630) 978-6200
Rush - Copley Medical Center Rush-Copley is proud to be the leading provider of health...
?
mi
from
Aurora, IL
Click here to add this to my saved trials
Baldwin Park, California 91706
?
mi
from
Baldwin Park, CA
Click here to add this to my saved trials
Baltimore, Maryland 21237
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Baltimore, Maryland 21229
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
6701 N Charles St
Baltimore, Maryland 21204
(443) 849-2000
Greater Baltimore Medical Center The 255-bed medical center (acute and sub-acute care) is located on...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Baltimore, Maryland
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
489 State St
Bangor, Maine 04401
(207) 973-7000
Eastern Maine Medical Center Located in Bangor, Eastern Maine Medical Center (EMMC) serves communities throughout...
?
mi
from
Bangor, ME
Click here to add this to my saved trials
155 5th St NE
Barberton, Ohio 44203
(330) 615-3000
Summa Barberton Hospital Summa Barberton Hospital is a full member of Summa Health System and...
?
mi
from
Barberton, OH
Click here to add this to my saved trials
Baton Rouge, Louisiana 70809
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
Baton Rouge, Louisiana 70806
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
Baton Rouge, Louisiana 70809
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
265 Fremont St
Battle Creek, Michigan 49017
(269) 245-8166
Bronson Battle Creek As a proud member of the Battle Creek community, we believe everyone...
?
mi
from
Battle Creek, MI
Click here to add this to my saved trials
Bay City, Michigan 48708
?
mi
from
Bay City, MI
Click here to add this to my saved trials
?
mi
from
Beachwood, OH
Click here to add this to my saved trials
Beaufort, South Carolina 29902
?
mi
from
Beaufort, SC
Click here to add this to my saved trials
Beaumont, Texas 77702
?
mi
from
Beaumont, TX
Click here to add this to my saved trials
Bedford, Texas 76022
?
mi
from
Bedford, TX
Click here to add this to my saved trials