Medication Development in Alcoholism: Investigating Glucocorticoid Antagonists

Inclusion Criteria:

- Male or female volunteers, 18-65 years of age

- Meets DSM-IV criteria for current alcohol dependence

- Subjects will not be seeking treatment because the medication studies are not
treatment trials

- Subjects must be abstinent a minimum of 3 days (but not more than 7 days) prior to
the human lab session

- Negative BAC and a CIWA score of < 8 at screening and time of lab session to
eliminate acute alcohol or withdrawal effects on dependent measures

- Subjects must be able to complete and understand questionnaires and study procedures
in English and sign an informed consent

Exclusion Criteria:

- Significant medical disorders that will increase potential risk or interfere with
study participation as determined by the Study Physician

- Female subjects with childbearing potential who are pregnant, nursing, or refuse to
use double barrier (non-hormonal) methods of birth control for the duration of the
study and one month thereafter

- Meets DSM-IV criteria for a major Axis I disorder including mood or anxiety disorders
or substance dependence disorders other than alcohol or nicotine dependence

- History of allergy or hypersensitivity to the study drugs or the ingredients

- Treatment within the month prior to screening with 1.) an investigational drug or
vaccine; 2.) drugs that may influence study outcomes, e.g., disulfiram (Antabuse),
naltrexone (ReVia), acamprosate (Campral), anticonvulsants, antidepressants.

- In need of or currently taking any psychoactive medications.