Two Interventions for Early Stage Dementia: A Comparative Efficacy Trial
| Status: | Completed |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/7/2015 |
| Start Date: | February 2012 |
| End Date: | December 2014 |
| Contact: | Amy Moore, M.S. |
| Email: | amoore@u.washington.edu |
| Phone: | 206-616-5550 |
Alzheimer's disease (AD) is increasing exponentially, with a projected quadrupling of cases
by the mid 21st century. Individuals with AD are at increased risk for a host of medical and
psychiatric conditions, and evidence is accumulating supporting the efficacy and
effectiveness of psychosocial interventions for improving their mood, function, health, and
quality of life. Such interventions are likely to be most effective when they are
implemented during the early stages of dementia, when individuals and their family members
are coping with the initial diagnosis and associated changes in abilities and activities.
Recent randomized clinical trials by the Principal Investigator and colleagues have
developed two non-pharmacologic interventions to reduce the social, psychological, physical,
and behavioral impact of dementia. This investigation is focused on facilitating their
translation into ongoing community-based programs, such as those provided by Alzheimer's
Association chapters, senior centers, retirement homes, and other health care providers. The
core content of each intervention has been retained in order to maintain or improve their
efficacy, and each has been modified to a 4-week group format to increase efficiency of
delivery. These modified interventions (ESML-Social and ESML-Ex) will be compared to each
other and to a usual care (UC) control group. Outcomes will be assessed at baseline, 1-month
post treatment, and 4 month follow-up. Primary outcomes at the 1-month assessment include:
social activity participation, family communication, physical activity participation, and
physical function. Primary outcomes at 4-month follow up include overall quality of life and
depression. It is hypothesized that ESML-Ex and ESML-Social both will have greater
improvements than UC. It is hypothesized that ESML-Social will have greater improvements in
social participation and family communication than ESML-Ex and UC. It is hypothesized that
ESML-Ex will have greater improvements in physical activity participation and physical
functioning than ESML-Social and UC. If successful, these 4-week programs may be developed
into "modules" that can be incorporated into programming for individuals with early stage
dementia in a variety of community settings.
by the mid 21st century. Individuals with AD are at increased risk for a host of medical and
psychiatric conditions, and evidence is accumulating supporting the efficacy and
effectiveness of psychosocial interventions for improving their mood, function, health, and
quality of life. Such interventions are likely to be most effective when they are
implemented during the early stages of dementia, when individuals and their family members
are coping with the initial diagnosis and associated changes in abilities and activities.
Recent randomized clinical trials by the Principal Investigator and colleagues have
developed two non-pharmacologic interventions to reduce the social, psychological, physical,
and behavioral impact of dementia. This investigation is focused on facilitating their
translation into ongoing community-based programs, such as those provided by Alzheimer's
Association chapters, senior centers, retirement homes, and other health care providers. The
core content of each intervention has been retained in order to maintain or improve their
efficacy, and each has been modified to a 4-week group format to increase efficiency of
delivery. These modified interventions (ESML-Social and ESML-Ex) will be compared to each
other and to a usual care (UC) control group. Outcomes will be assessed at baseline, 1-month
post treatment, and 4 month follow-up. Primary outcomes at the 1-month assessment include:
social activity participation, family communication, physical activity participation, and
physical function. Primary outcomes at 4-month follow up include overall quality of life and
depression. It is hypothesized that ESML-Ex and ESML-Social both will have greater
improvements than UC. It is hypothesized that ESML-Social will have greater improvements in
social participation and family communication than ESML-Ex and UC. It is hypothesized that
ESML-Ex will have greater improvements in physical activity participation and physical
functioning than ESML-Social and UC. If successful, these 4-week programs may be developed
into "modules" that can be incorporated into programming for individuals with early stage
dementia in a variety of community settings.
Inclusion Criteria:
- Dementia diagnosis
- Clinical Dementia Rating Scale score
- Care Partner agrees to participate with care recipient
- Care recipient lives in the community or a retirement home
- Both care partner and recipient speak English
Exclusion Criteria:
- Significant physical or psychiatric illness in either care partner or care recipient
that would prevent participant in a exercise program
- Planning to move out of study area during the 4 month follow-up period
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