Salvage Ovarian FANG™ Vaccine + Bevacizumab

Inclusion Criteria:

1. Histologically confirmed papillary serous or endometrioid ovarian cancer.

2. Previous randomization to Gradalis, Inc. protocol CL-PTL 105; observation arm (Group
B) or patients with vaccine prepared for CLPTL 105 but not otherwise qualifying.

3. Recurrent cisplatinum resistant/refractory disease (defined as the appearance of any
measurable or evaluable lesion or as asymptomatic CA-125 levels greater than 100 u/mL
at two consecutive measurements with no intervening therapy.

4. Successful manufacturing of 4 vials of Vigil™ vaccine.

5. Recovered from all clinically relevant toxicities related to prior therapies.

6. ECOG PS 0-2 prior to Vigil™ vaccine administration.

7. Normal organ and marrow function as defined below:

1. Absolute granulocyte count ≥1,500/mm3

2. Absolute lymphocyte count ≥ 200/mm3

3. Platelets ≥100,000/mm3

4. Total bilirubin ≤1.5 x ULN

5. AST(SGOT)/ALT(SGPT)/alkaline phosphatase ≤2.5 x ULN

6. Creatinine <1.5 mg/dL

7. INR < 1.5

8. Baseline blood pressure must be under 140/90

9. Urine protein-to-creatinine ratio < 1.0 mg/dL.

10. Patients must be off all "statin" drugs for ≥ 2 weeks prior to initiation of therapy.

11. Ability to understand and the willingness to sign a written informed protocol specific
consent.

Exclusion Criteria:

1. Surgery involving general anesthesia, chemotherapy, radiotherapy, steroid therapy, or
immunotherapy within 4 weeks prior to vaccination. Chemotherapy within 3 weeks prior
to vaccination. Steroid therapy within 1 week prior to vaccination.

2. Major surgery within 6 weeks or minor surgery within 2 weeks of receiving bevacizumab.

3. Patient must not have received any other investigational agents within 4 weeks prior
to study entry.

4. Patients who require parenteral hydration of nutrition and have evidence of partial
bowel obstruction or perforation.

5. Patients with history of brain metastases.

6. Patients with compromised pulmonary disease.

7. Short term (<30 days) concurrent systemic steroids ≤ 0.25 mg/kg prednisone per day
(maximum 7.5 mg/day) and bronchodilators (inhaled steroids) are permitted; other
steroid regimens and/or immunosuppressives are excluded.

8. Prior splenectomy.

9. Prior malignancy (excluding nonmelanoma carcinomas of the skin and carcinoma in situ
cervix) unless in remission for ≥ 2 years.

10. Kaposi's Sarcoma.

11. Patients with active bleeding or pathologic conditions that carry high risk of
bleeding such as a known bleeding disorder, coagulopathy, or tumor involving major
blood vessels.

12. History of Stroke/Transient Ischemic Attack

13. Use of bleeding diathesis

14. Use of anti-coagulants

15. Patients with clinically significant cardiovascular disease including any of the
following:

1. Significant cardiac conduction abnormalities (e.g., PR interval > 0.24 sec or
second or third degree AV block.

2. Uncontrolled hypertension, defined as systolic blood pressure (BP) > 150 mm Hg or
diastolic BP > 90 mm Hg.

3. Myocardial infarction, cardiac arrhythmia, or unstable angina within the past 6
months.

4. New York Heart Association grade II or greater congestive heart failure.

5. Serious cardiac arrhythmia requiring medication.

6. Grade II or greater peripheral vascular disease except episodes of ischemia < 24
hours induration that are managed non-surgically and without permanent deficit

7. History of cerebrovascular accident within the past 6 months.

8. No significant traumatic injury within the past 28 days.

16. Uncontrolled infection or psychiatric illness/social situations that would limit
compliance with study requirements.

17. Patients with known HIV.

18. Patients with chronic Hepatitis B and C infection.

19. Patients with uncontrolled autoimmune diseases.