An Observational Study to Evaluate The Relationship of Nasal Mucus Properties and Symptoms

This study involves collecting and analyzing nasal mucus to see if there are changes in mucus
properties during the course of a cold or episode of allergic rhinitis. Outcome measures
include SNOT20 questionnaire, nasal secretion collection, acoustic rhinometry on the fifth
and fourteenth day of symptoms. The investigators will also collect SNOT20 questionnaires on
the tenth and twenty-eighth day.

Inclusion Criteria:

- Male and female subjects 12 years of age and older with acute nasal discharge fewer
than 7 days or a history suggesting nasal allergic symptoms for at least 1 year.
Internet access required during the course of the study. Patients must be symptomatic
at screening.

Exclusion Criteria:

- Symptoms suggesting bacterial rhinosinusitis such as fever ≥ 101ºF/38.3ºC, facial
swelling, and serve tooth pain. History of CRS or sinus/nasal surgery for this
condition within 6 months before screening. History of respiratory signs and symptoms
due to allergic rhinitis. Therapy with bronchodilators, nasal steroids, oral
corticosteroids in the past 30 days. Therapy with antihistamines, nasal (Neti)
washings, or decongestants in the past 24 hours. Use of any OTC cold or allergy
medication 24 hours before study visits requires a 24 hour washout phase