Phase I Trial of Ganetespib, Capecitabine, and Radiation in Rectal Cancer
| Status: | Completed |
|---|---|
| Conditions: | Colorectal Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | May 2012 |
| End Date: | June 2015 |
The purpose of this study is to find out what effects, good and/or bad, the combination of
the study drug, capecitabine, and radiation have on you and your cancer. Capecitabine,
radiation, and the study drug kill cancer cells in different ways. Giving these treatments
together may make your cancer shrink or slow down its growth more than it would if you got
treated with capecitabine and radiation alone.
This is a Phase I drug study of ganetespib given together with capecitabine and radiation in
patients with locally advanced rectal cancer. Ganetespib is an experimental drug; not
approved by the Food and Drug Administration (FDA). The other two, capecitabine and
radiation, are approved by FDA for use in rectal cancer.
In this study, the investigators will test different dosages of the "investigational"
(experimental) drug, called ganetespib (the study drug). The study drug is "investigational"
because it is not approved by the FDA for use. The study drug has been previously tested in
humans. The study uses a well-established process of slowly increasing drug dosage to
determine the highest dosage that can be given without causing serious side effects. In
addition, the study will help researchers to determine what the side effects and drug
interactions might be.
The study will also look at the drug's pharmacokinetics (PK). PK is how the study drug and
capecitabine with radiation work in your body (for example how long the drugs last in your
body.)
the study drug, capecitabine, and radiation have on you and your cancer. Capecitabine,
radiation, and the study drug kill cancer cells in different ways. Giving these treatments
together may make your cancer shrink or slow down its growth more than it would if you got
treated with capecitabine and radiation alone.
This is a Phase I drug study of ganetespib given together with capecitabine and radiation in
patients with locally advanced rectal cancer. Ganetespib is an experimental drug; not
approved by the Food and Drug Administration (FDA). The other two, capecitabine and
radiation, are approved by FDA for use in rectal cancer.
In this study, the investigators will test different dosages of the "investigational"
(experimental) drug, called ganetespib (the study drug). The study drug is "investigational"
because it is not approved by the FDA for use. The study drug has been previously tested in
humans. The study uses a well-established process of slowly increasing drug dosage to
determine the highest dosage that can be given without causing serious side effects. In
addition, the study will help researchers to determine what the side effects and drug
interactions might be.
The study will also look at the drug's pharmacokinetics (PK). PK is how the study drug and
capecitabine with radiation work in your body (for example how long the drugs last in your
body.)
Patients with rectal cancer who meet the eligibility criteria will be offered to enroll on
the study. As part of the study patients will receive the standard of care capecitabine (825
mg/m² by mouth twice daily) and radiation. Patients will start on ganetespib (STA9090) at a
set dose level.
The treatment consists of two parts. In the first part patients will receive ganetespib at
full dose twice a week through the vein for two weeks. At the end of two weeks, a biopsy of
the tumor will be performed to evaluate the effect of the drug on the tumor. In the second
phase, patients will receive capecitabine, radiation and ganetespib at a specified dose
level for 5 to 6 weeks. After completion of this phase, patients will have surgery to remove
the tumor. Each three patients will be treated at a specified dose level. Patients will be
monitored at least once a week for side effects. If there are no side effects in three
consecutive patients, then the investigators will treat the next three patients at a higher
dose level.
the study. As part of the study patients will receive the standard of care capecitabine (825
mg/m² by mouth twice daily) and radiation. Patients will start on ganetespib (STA9090) at a
set dose level.
The treatment consists of two parts. In the first part patients will receive ganetespib at
full dose twice a week through the vein for two weeks. At the end of two weeks, a biopsy of
the tumor will be performed to evaluate the effect of the drug on the tumor. In the second
phase, patients will receive capecitabine, radiation and ganetespib at a specified dose
level for 5 to 6 weeks. After completion of this phase, patients will have surgery to remove
the tumor. Each three patients will be treated at a specified dose level. Patients will be
monitored at least once a week for side effects. If there are no side effects in three
consecutive patients, then the investigators will treat the next three patients at a higher
dose level.
Inclusion Criteria:
- Must be at least 18 years of age
- Stage II or III histologically-proven rectal adenocarcinoma. The distal border of the
tumor must be at or below the peritoneal reflection, defined as within 12 centimeters
of the anal verge by proctoscopic examination.
- Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1
- Adequate hematologic function as defined by:
- Absolute neutrophil count ≥ 1,500 cells/µL
- Platelets ≥ 100,000/µL
- Hemoglobin ≥ 9.0g/dL
- Adequate hepatic function as defined by:
- Total bilirubin ≤ 1.5 x the upper limit of normal (ULN)
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 x ULN
- Albumin ≥ 3.0 g/dL
- Adequate renal function as defined by:
- Serum creatinine ≤ 1.5 x ULN
- Calculated creatinine clearance of ≥ 50 mL/min
- International normalized ratio (INR) ≤ 1.5. Anticoagulation is allowed only with low
molecular weight heparin (LMWH). Patient receiving LMW heparin on stable therapeutic
dose for more than 2 weeks or with factor Xa level < 1.1 U/mL are allowed on the
trial.
- Willingness and ability to comply with scheduled visits, treatment plans, laboratory
tests, and other study procedures
- Ability to understand and willingness to sign a written informed consent document
- Female subjects of childbearing potential and males must agree to use adequate
contraception (e.g., hormonal or barrier method of birth control; abstinence) for the
duration of study treatment
- Female subjects of childbearing age must have a negative serum pregnancy test at
study entry.
Exclusion Criteria:
- History of previous radiation therapy to the abdomen or pelvis
- History of previous chemotherapy for rectal cancer
- Major surgery within 4 weeks prior to first dose of ganetespib
- Poor venous access for study drug administration. The study drug must be administered
via peripheral venous access or through vascular access devices (VADs) (such as ports
and peripherally-inserted central catheters [PICCS] containing silicone catheters.
Use of VADs with catheters made of any other material is not allowed.
- History of severe allergic or hypersensitivity reactions to excipients (e.g.,
Polyethylene glycol [PEG] 300 and Polysorbate 80)
- Baseline corrected QT interval (QTc) > 450 msec or previous history of QT
prolongation while taking other medications
- Ventricular ejection fraction (Ef) ≤ 55% at baseline
- Treatment with chronic immunosuppressants (e.g., cyclosporine following
transplantation)
- Women who are pregnant or lactating
- Uncontrolled intercurrent illness
- Other medications, or severe acute/chronic medical or psychiatric condition, or
laboratory abnormality that may increase the risk associated with study participation
or study drug administration, or may interfere with the interpretation of study
results, and in the judgment of the investigator would make the subject inappropriate
for entry into this study
- Patients must be able to take oral medications.
- Unequivocal metastatic disease on computed tomography or chest X-ray
- Clinically significant comorbid conditions such as cardiovascular disease or
significant peripheral vascular (e.g., uncontrolled hypertension, myocardial
infarction, unstable angina) within 6 months of study entry, serious cardiac
arrhythmia requiring medication, and uncontrolled infection.
- Clinical evidence of bleeding diathesis or coagulopathy
- Significant involvement of the bladder by the tumor
- Patients with prior malignancies, including pelvic cancer, are eligible if they have
been disease free for > 5 years. Patients with prior in situ carcinomas are eligible
provided there was complete removal.
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