Blood and Cerebrospinal Fluid for Pediatric Brain Tumor Research
| Status: | Completed |
|---|---|
| Conditions: | Brain Cancer, Women's Studies |
| Therapuetic Areas: | Oncology, Reproductive |
| Healthy: | No |
| Age Range: | 1 - 21 |
| Updated: | 4/21/2016 |
| Start Date: | July 2011 |
| End Date: | April 2012 |
Collection of Blood and Cerebrospinal Fluid for Pediatric Brain Tumor Research
In normal patients, blood and cerebrospinal fluid (CSF) contain circulating cells and other
molecules such as proteins and nucleic acids. In patients with central nervous system (CNS)
and other conditions, the levels of these molecules may be altered. In several other studies
at our institution, the investigators are investigating such molecules in tumor specimens as
well as the blood and cerebrospinal fluid of pediatric patients with CNS tumors. However,
these levels are difficult to interpret without comparing them to levels in patients without
CNS tumors. The investigators propose a study to collect small amounts of blood and
cerebrospinal fluid from pediatric patients without CNS tumors who are undergoing a
diagnostic or therapeutic neurosurgical procedure aimed at addressing altered CSF dynamics.
molecules such as proteins and nucleic acids. In patients with central nervous system (CNS)
and other conditions, the levels of these molecules may be altered. In several other studies
at our institution, the investigators are investigating such molecules in tumor specimens as
well as the blood and cerebrospinal fluid of pediatric patients with CNS tumors. However,
these levels are difficult to interpret without comparing them to levels in patients without
CNS tumors. The investigators propose a study to collect small amounts of blood and
cerebrospinal fluid from pediatric patients without CNS tumors who are undergoing a
diagnostic or therapeutic neurosurgical procedure aimed at addressing altered CSF dynamics.
Inclusion Criteria:
- Children without central nervous system tumors who are undergoing a neurosurgical
procedure to address hydrocephalus during which CSF will be obtained
- Between the ages of 1 year and 21 years
- Patients must be having blood draws, lumbar punctures or CSF sampling from Ommaya
reservoirs or VPS as part of routine clinical care.
Exclusion Criteria:
- Patients who do not require routine blood draws and/or CSF collection as part of
their routine clinical care
- Patients who are considered too ill to participate as determined by their treating
physician
- Patients with documented bacterial of viral infections of the CSF, brain parenchyma
and/or neurosurgical devices and/or
- Patients with suspected de-myelinating conditions
- Patients who are pregnant or lactating.
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