Perindopril Amlodipine for the Treatment of Hypertension

Inclusion Criteria:

- Essential hypertension

- For female subjects, a negative serum pregnancy test

- Ability to provide written informed consent

Exclusion Criteria:

- Night shift workers whose work hours include midnight to 4:00 a.m.

- Secondary hypertension

- An arm size that precludes the use of the digital blood pressure monitor cuff (arm
size > 42 cm)

- Renal dysfunction, severe renal impairment, bilateral renal artery stenosis, renal
artery stenosis in a solitary kidney, subjects with only 1 kidney, or post-renal
transplant subjects

- Female subjects who are pregnant, planning to become pregnant

- History of malignancy within 5 years

- Primary aldosteronism

- Heart failure (NYHA functional class 3-4), hypertrophic obstructive cardiomyopathy,
or hemodynamically relevant stenosis of the aortic or mitral valve

- Significant cardiac arrhythmias, MI, stroke, CABG, PTCA, unstable angina

- Known hypersensitivity to any component of the study drugs

Other protocol-defined inclusion/exclusion criteria may apply