Effects of Electroconvulsive Therapy (ECT) in Bipolar Depression
| Status: | Completed |
|---|---|
| Conditions: | Depression, Psychiatric, Bipolar Disorder |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/18/2012 |
| Start Date: | April 2011 |
| End Date: | April 2013 |
| Contact: | Erin Ryan |
| Phone: | 617-855-2937 |
A Study of the Acute and Chronic Effects of Electroconvulsive Therapy on Glutamatergic Neurotransmission in Bipolar Depression
The primary purpose of this study is to use magnetic resonance spectroscopy (MRS) to measure
the levels of several brain chemicals including, but not limited to, glutamate, glutamine,
and N-acetylaspartate, before and after treatment with ECT. In addition to MRS, the
investigators will use several other MRI techniques including structural MRI, resting state
functional MRI (fMRI), and diffusion tensor imaging (DTI) to measure how the structure and
function of the brain changes with ECT.
The investigators hypothesize that the Gln/Glu ratio is increased in the anterior cingulate
cortex (ACC), but not the parieto-occipital cortex (POC), following the first ECT treatment.
Inclusion Criteria:
- Male or female age 18-55
- Meets DSM-IV criteria for Bipolar Disorder Type I, II, or NOS with current episode
depressed
- Has been scheduled to be evaluated by an ECT consultant from the McLean Hospital ECT
service
- Current score of greater than or equal to 24 on the Montgomery-Asberg Depression
Rating Scale (MADRS)
Exclusion Criteria:
- Unwillingness or inability to provide informed consent
- Lifetime history of schizophrenia
- DSM-IV diagnosis of alcohol or substance dependence, with the exception of nicotine
dependence, within three months prior to screening
- Positive urine toxicology screen at screening (NOTE: Participants with a positive
urine toxicology screen who are prescribed benzodiazepine, stimulant, or opiate
medications by their physician will be permitted to enroll in the study as long as
they do not meet abuse or dependence criteria for these substances)
- Female participants with a positive urine pregnancy test at screening
- Pregnancy. Females of childbearing potential must be using an effective contraceptive
method (e.g., abstinence, prescription oral contraceptives, contraceptive injections,
MRI-safe intrauterine device, double-barrier method, male partner sterilization)
- Any contraindications to having an MRI scan, including cardiac pacemakers, metal
vascular clips or stents, artificial heart valves, certain kinds of prostheses, brain
stimulator devices, implanted drug pumps, ear implants, eye implants or known metal
fragments in eyes, exposure to shrapnel or metal filings (wounded in military combat,
sheetmetal workers, welders, and others), transdermal drug delivery systems, and
certain tattoos with metallic ink. NOTE: Participants will be screened for these
conditions at screening, and will be required to fill out a standard MRI screening
form at the Brain Imaging Center, which will be reviewed by an MRI technician prior
to each MRI scan
- Scheduled to receive first ECT treatment on a Friday
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