GRoup A StrePtococcus
| Status: | Recruiting |
|---|---|
| Conditions: | Other Indications |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 4 - 16 |
| Updated: | 12/27/2018 |
| Start Date: | May 1, 2011 |
| End Date: | July 2020 |
| Contact: | Cherie Schommer, BA |
| Email: | schommer2@wisc.edu |
| Phone: | 608-262-2631 |
Gene Expression in Isolates of Group A Streptococci Recovered From Patients Who Are Carriers
The purpose of the research is to help understand why some children become carriers of strep
and whether children who are carriers need to be treated with antibiotics.
and whether children who are carriers need to be treated with antibiotics.
The objective of this investigation is to develop a method to distinguish children who are
acutely infected with GAS from those who are carriers. If the carrier state can be
differentiated from acute infection we will be able to avoid unnecessary treatment of
children with pharyngitis or other respiratory symptoms from whom GAS are recovered but who
are not truly infected with GAS. This will facilitate the primary prevention of acute
rheumatic fever globally without enhancing antimicrobial resistance. The specific aim of this
study is to identify 30 children with acute pharyngitis due to Group A streptococcus (GAS)
and 30 children who are pharyngeal carriers of GAS.
Thirty percent of children 4 to 16 years of age with acute pharyngitis occurring between
October and May will have a positive culture or rapid antigen detection test for GAS.
Approximately 10-15% of these children with pharyngitis and a positive culture or rapid
antigen detection test (RADT) for GAS will be carriers.
acutely infected with GAS from those who are carriers. If the carrier state can be
differentiated from acute infection we will be able to avoid unnecessary treatment of
children with pharyngitis or other respiratory symptoms from whom GAS are recovered but who
are not truly infected with GAS. This will facilitate the primary prevention of acute
rheumatic fever globally without enhancing antimicrobial resistance. The specific aim of this
study is to identify 30 children with acute pharyngitis due to Group A streptococcus (GAS)
and 30 children who are pharyngeal carriers of GAS.
Thirty percent of children 4 to 16 years of age with acute pharyngitis occurring between
October and May will have a positive culture or rapid antigen detection test for GAS.
Approximately 10-15% of these children with pharyngitis and a positive culture or rapid
antigen detection test (RADT) for GAS will be carriers.
Inclusion Criteria:
- Children ages 4-16 years
- Positive rapid antigen detection test for group A streptococcus
- English speaking
Exclusion Criteria:
- Treatment with antibiotics in the last 30 days.
- Allergic to beta lactam antibiotics.
We found this trial at
3
sites
Madison, Wisconsin
Principal Investigator: Gregory Demuri, MD
Phone: 608-262-9531
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Madison, Wisconsin 53717
Principal Investigator: Gregory DeMuri, MD
Phone: 608-262-9531
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Madison, Wisconsin 53792
Principal Investigator: Ellen Wald, MD
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