Study of Amiodarone Given Before Lung Surgery to Prevent Atrial Fibrillation After Lung Resection



Status:Completed
Conditions:Atrial Fibrillation, Lung Cancer, Cancer
Therapuetic Areas:Cardiology / Vascular Diseases, Oncology
Healthy:No
Age Range:18 - Any
Updated:4/2/2016
Start Date:February 2006
End Date:March 2011
Contact:Malcolm M DeCamp, MD
Email:mdecamp@bidmc.harvard.edu
Phone:617-632-8386

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Phase III Study of Preoperative Amiodarone for Prevention of Atrial Fibrillation After Lung Resection

Atrial fibrillation is a very common complication of pulmonary resection. Patients who
develop atrial fibrillation require additional treatment and are more likely to stay in the
hospital for longer period of time increasing the costs associated with the operation. We
propose a randomized controlled trial to see if oral amiodarone given for one week before
surgery can prevent atrial fibrillation after pulmonary resection. We plan to evaluate the
incidence of atrial fibrillation in patients who received preoperative amiodarone and
compare them to the incidence of atrial fibrillation in patients who did not received
preoperative amiodarone.


Inclusion Criteria:

- Resectable lung nodule or mass

Exclusion Criteria:

- Allergy to amiodarone

- Currently taking amiodarone

- Documented atrial fibrillation within past 12 months

- Known pulmonary fibrosis

- Known hepatic dysfunction

- Thyroid disease

- 2nd or 3rd degree heart block

- Severe SA node disease

- Bradycardia-induced syncope

- Pregnancy
We found this trial at
1
site
330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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from
Boston, MA
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