Study of LY2886721 in Mild Cognitive Impairment Due to Alzheimer's Disease or Mild Alzheimer's Disease

Inclusion Criteria:

Meets criteria for MCI due to AD or Mild AD

All participants will be required to undergo assessment via the Mini Mental State
Examination (MMSE) scale at screening

- Participants with MMSE scores of 20 to 26, inclusive, may be enrolled provided they
meet the criteria for mild AD, as follows:

- Participant meets the National Institute of Neurological and Communicative
Disorders and Stroke/Alzheimer's Disease and Related Disorders Association
(NINCDS/ADRDA) criteria for probable AD

- Clinical Dementia Rating Scale (CDR) score of 0.5 or 1

- Positive scan for the presence of amyloid beta

- Participants with MMSE of 27 to 30, inclusive, may be enrolled as participants with
MCI due to AD provided they meet the following criteria:

- Gradual and progressive change in memory function as reported by the participant
or a caregiver during a period of more than 6 months

- Free and Cued Selective Reminding Test with Immediate Recall (FCSRT-IR): free
recall ≤22 and total recall ≤46

- Absence of dementia

- Preservation of functional independence

- Exclusion of other potential (vascular, traumatic, or medical) causes of
cognitive decline, where possible

- Positive scan for the presence of amyloid beta

- Women must be postmenopausal

- Men are required to use an approved barrier method of contraception if their partners
are pregnant, or of childbearing potential and not using approved contraceptive
methods

Exclusion Criteria:

- Participant in another drug or device study

- Have a history of frontotemporal dementia, Lewy body disease, vascular dementia,
Huntington's disease, Parkinson's disease, progressive supranuclear palsy (PSNP), or
other movement disorder

- Participants are not on a stable standard of care (acetylcholinesterase inhibitors,
memantine) initiated less than 2 months prior to entry or have less than 4 weeks of
stable therapy. Note: Stable standard of care is allowed.

- Have had a serious infectious disease affecting the brain in the past 5 years

- Have had a serious or repeat head injury

- Have significant retinal impairment or disease

- Have had a stroke or other circulation problems that are affecting current health

- Have had a seizure

- Have major depressive disorder and are not on a stable dose of medication.
Participants who no longer meet the Diagnostic and Statistical Manual of Mental
Disorders, Fourth Edition-Text Revision (DSM-IV) criteria for major depression may be
included

- History of schizophrenia, bipolar disorder, or severe mental illness

- History of alcohol or drug abuse

- Have asthma, chronic obstructive pulmonary disease (COPD), or other breathing disease
that is not controlled with medicine

- Have human immunodeficiency virus (HIV) or syphilis

- Are taking blood thinners