Investigating the Use of Fluorescence Imaging in Endometrial Cancer Surgery

In many cancer types, such as breast cancer and melanoma, sentinel node assessment has
become the standard of care surgical treatment. Sentinel nodes are the first lymph nodes to
which cancer cells are likely to spread from a primary tumor. Removal of a sentinel node for
examination accurately predicts whether the cancer has spread to other nodes further along
in the nodal chain. Fluorescence imaging with ICG dye (Indocyanine Green) has been used to
detect lymph nodes in patients with gastric, colorectal and breast cancer. To date, the use
of this technique in endometrial cancer has not been reported.

Inclusion Criteria:

- Biopsy proven endometrial carcinoma

- Must have planned to undergo standard endometrial cancer staging surgery as part of
their routine clinical care

- Must be 18 years of age and older

- Must be able to comply with all the study procedures

Exclusion Criteria:

- Significant liver disease, cirrhosis or liver insufficiency with abnormal liver
function tests, with total bilirubin > 1.5 times normal, and/or SGOT > 2 times normal

- Uremia, serum creatinine > 2.0 mg/dl

- Previous history of adverse reaction or allergy to ICG dye, iodine, shellfish, or
iodine dyes

- Previous lymphadenectomy or surgery that could change the uterine lymphatic drainage

- Pregnant

- Currently participating in a drug, biologic and/or device treatment study

- Any medical condition that would normally prevent someone from receiving general
anesthesia or undergoing standard surgical procedures