Phase 1/2, Open-label, Dose-escalation Study of IONIS-STAT3Rx, Administered to Patients With Advanced Cancers
| Status: | Completed |
|---|---|
| Conditions: | Cancer, Cancer, Lymphoma |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 6/27/2018 |
| Start Date: | February 27, 2012 |
| End Date: | March 23, 2016 |
A Phase 1/2 Study of ISIS 481464, an Antisense Oligonucleotide Inhibitor of STAT3, Administered to Patients With Advanced Cancers
This is a Phase 1/2, open-label, dose-escalation, dose-expansion study for the treatment of
patients with advanced cancers. Eligible patients with DLBCL or other advanced lymphomas will
be enrolled into the dose-expansion cohort.
patients with advanced cancers. Eligible patients with DLBCL or other advanced lymphomas will
be enrolled into the dose-expansion cohort.
Inclusion Criteria:
- Aged 18 years or older
- Tumors that are relapsed or refractory to at least 1 prior anti-cancer systemic
therapy and for which no standard therapy exists
- Expansion cohort only: Advanced lymphoma confirmed by histopathology
- Measurable or evaluable disease according to RECIST for solid tumors or according to
IWRC for NHL tumors
- ECOG Performance Status less than or equal to 2
- Life expectancy greater than 12 weeks in the opinion of the Investigator
Exclusion Criteria:
- Any active or uncontrolled infection
- NYHA Grade II or greater congestive heart failure
- History of myocardial infarction within 6 months prior to screening
- Prior radiation therapy, chemotherapy, hormonal therapy, or immunotherapy within 4
weeks prior to screening or 5 half-lives of the therapy, whichever is shorter
We found this trial at
9
sites
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Yale Cancer Center Yale Cancer Center combines a tradition of innovative cancer treatment and quality...
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660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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Mayo Clinic Arizona Mayo Clinic in Arizona provides medical care for thousands of people from...
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