Role of Infected Blood Dendritic Cells in Heart Disease Risk
| Status: | Completed |
|---|---|
| Conditions: | Dental |
| Therapuetic Areas: | Dental / Maxillofacial Surgery |
| Healthy: | No |
| Age Range: | 40 - Any |
| Updated: | 2/7/2015 |
| Start Date: | March 2012 |
| End Date: | March 2014 |
| Contact: | Christopher Cutler, DDS, PhD |
| Email: | chcutler@georgiahealth.edu |
| Phone: | 7067212442 |
Peripheral Blood Dendritic Cells and Periodontitis
The investigators hypothesize that blood dendritic cells harbor pathogens from the oral
cavity in chronic periodontitis and disseminate these pathogens to atherosclerotic plaques.
cavity in chronic periodontitis and disseminate these pathogens to atherosclerotic plaques.
To address this hypothesis, a clinical study in humans with moderate to severe chronic
periodontitis has been designed. This is an interventional study involving scaling and root
planing and two arms: 1. treatment with PO amoxocillin/metronidazole plus chlorhexidine oral
rinse; 2. no antibiotics or oral rinse. It is expected that the antibiotics plus
chlorhexidine will prevent the dendritic cell response to infection (bacteremia) elicited by
scaling and root planing.
periodontitis has been designed. This is an interventional study involving scaling and root
planing and two arms: 1. treatment with PO amoxocillin/metronidazole plus chlorhexidine oral
rinse; 2. no antibiotics or oral rinse. It is expected that the antibiotics plus
chlorhexidine will prevent the dendritic cell response to infection (bacteremia) elicited by
scaling and root planing.
Inclusion Criteria:
- generalized moderate to severe chronic periodontitis
Exclusion Criteria:
- diabetes
- antibiotics treatment within 3 months
- treatment with steroids, phenytoin, cyclosporin, coumadin
- presence of conditions requiring prophylactic antibiotics per AHA
- cancer, HIV, hepB, lupus, prediagnosed heart disease, renal disease
- smoker
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