Anthropometry in Gastroesophageal Reflux Disease and Esophageal Injury

The investigators will study 100 adult subjects over the age of 18 from the esophageal
motility lab who are undergoing clinically indicated 24 hour pH impedance and/or pH studies
off acid suppressing medication.. These subjects will not have a prior history of esophageal
surgery, or diagnosis of BE. The investigators will obtain consent for taking anthropometric
measurements (Waist and hip circumference), and the results of their study. Only those
subjects that successfully complete the 24h pH/impedance studies will be included. Subjects
will also undergo clinically indicated endoscopy. The investigators will consent these
subjects to obtain 4 biopsies (bx) from the gastroesophageal (GE) junction and 4 bx from 5
cm above the GE junction. These bio-specimens will be stored for assessment of tissue injury
(PGE2) and tissue immune-histochemistry of BE precursors (CDX1 and CDX2) at a later date.

Inclusion:

- Subjects over the age of 18 undergoing clinically indicated 24 hour pH impedance
and/or pH studies. Many will also undergo clinically indicated endoscopy, and consent
for acquiring tissue samples for future biomarker staining tests will be obtained.

- Able to give informed consent

Exclusion:

- Subjects with a prior history of esophageal surgery, or diagnosis of BE.