Impact of Impaired Cerebral Autoregulation on Postoperative Delirium in Elderly Patients Undergoing Spine Surgery
| Status: | Completed |
|---|---|
| Conditions: | Neurology, Psychiatric |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 70 - Any |
| Updated: | 4/21/2016 |
| Start Date: | March 2012 |
| End Date: | June 2014 |
The Impact of Impaired Cerebral Autoregulation on the Development of Postoperative Delirium in Elderly Patients Undergoing Spine Surgery
Delirium (confusion) after surgery is common and associated with a longer hospitl stay and
increased hopsital cost. There is very little information available about how often delirium
occurs and the complications associated with it. Elderly patients are at high risk for
delirium after surgery. This research is being done to measure how often delirium after
spine surgery occurs and to see if there are ways to predict if delirium will develop. The
results from this study will provide important information on a possible mechanism and
predictor of delirium.
increased hopsital cost. There is very little information available about how often delirium
occurs and the complications associated with it. Elderly patients are at high risk for
delirium after surgery. This research is being done to measure how often delirium after
spine surgery occurs and to see if there are ways to predict if delirium will develop. The
results from this study will provide important information on a possible mechanism and
predictor of delirium.
Delirium (confusion) after surgery is common and associated with a longer hospitl stay and
increased hopsital cost. This research is being done to measure how often delirium after
spine surgery occurs and to see if there are ways to predict if delirium will develop. We
hypothesize that impaired cerebral autoregulation may be a possible mechanism for
postoperative delirium. We will measure intraoperative cerebral autoregulation and assess
the relationship with postoperative dleirium. The results from this study will provide
important information on a possible mechanism and predictor of delirium.
increased hopsital cost. This research is being done to measure how often delirium after
spine surgery occurs and to see if there are ways to predict if delirium will develop. We
hypothesize that impaired cerebral autoregulation may be a possible mechanism for
postoperative delirium. We will measure intraoperative cerebral autoregulation and assess
the relationship with postoperative dleirium. The results from this study will provide
important information on a possible mechanism and predictor of delirium.
Inclusion Criteria:
1. ≥ 70 years old,
2. Undergoing any lumbar spine surgery, posterior cervical spine surgery, or anterior
cervical spine surgery > 2 levels
Exclusion Criteria:
1. MMSE < 15
2. Delirium at baseline
3. Inability to speak and understand English
4. Severe hearing impairment, resulting in inability to converse.
5. Planned use of intraoperative ketamine
6. Planned use of intraoperative remifentanil, except for airway management
pre-incision.
7. Arterial catheter not planned to be inserted
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