The Neurobiology of Expectancy and Pain Perception
| Status: | Completed |
|---|---|
| Conditions: | Chronic Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 21 - 50 |
| Updated: | 10/15/2017 |
| Start Date: | June 2012 |
| End Date: | October 2013 |
A Brain Imaging Study of the Analgesic Effect of Lidocaine and the Hyperalgesic Effect of Capsaicin
This study will use using fMRI (functional Magnetic Resonance Imaging) to elucidate how
contextual learning/expectation relieves or aggravates pain experience in the same cohort of
subjects and the same study session.
contextual learning/expectation relieves or aggravates pain experience in the same cohort of
subjects and the same study session.
Inclusion Criteria:
- a) Healthy male and female adults aged 21-50
- b) No contraindications to fMRI scanning
- c) Right handed
Exclusion Criteria:
- a) Current or past history of major medical, neurological, or psychiatric illness
- b) Pregnancy or breast feeding, menopause, and irregular menstrual cycles (length of
cycle must be within 26 to 32 days)
- c) Claustrophobia
- d) History of head trauma
- e) History of impaired elimination
- f) Instability of responses to experimental pain (see Study Procedures Section)
- g) Use of psychotropic drugs, hormone treatments (including hormonal birth control)
within 1 year
- h) Non-fluent speaker of English
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