Oral Trehalose Therapy to Reverse Arterial Aging in Middle-Aged and Older Adults
| Status: | Completed |
|---|---|
| Conditions: | Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 50 - 79 |
| Updated: | 4/21/2016 |
| Start Date: | May 2012 |
| End Date: | December 2015 |
The proposed study will assess the ability of a naturally occurring sugar to improve the
function of arteries with age. Overall, the proposed research project has the long-term
potential to influence clinical practice guidelines by establishing a novel, easy to
deliver, cost-effective therapy for treating age-associated arterial dysfunction and
reducing the risk of cardiovascular disease with age.
function of arteries with age. Overall, the proposed research project has the long-term
potential to influence clinical practice guidelines by establishing a novel, easy to
deliver, cost-effective therapy for treating age-associated arterial dysfunction and
reducing the risk of cardiovascular disease with age.
Inclusion Criteria:
- women must be postmenopausal
- body mass index (BMI) <40 kg/m2
- weight stable in the prior 3 months
- absence of clinical disease as determined by medical history, physical examination,
blood and urine chemistries, ankle-brachial index, and a graded exercise stress test
with monitoring of blood pressure and 12-lead ECG
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