OCT-guided LALAK in Children
| Status: | Completed |
|---|---|
| Conditions: | Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | Any - 18 |
| Updated: | 4/2/2016 |
| Start Date: | January 2012 |
| End Date: | January 2016 |
| Contact: | Cassandra Fink |
| Email: | CFink@chla.usc.edu |
| Phone: | (323) 361-2265 |
Randomized Clinical Trial of OCT-guided Laser-assisted Lamellar Anterior Keratoplasty in Children
The primary goal of the trial is to determine if laser-assisted lamellar anterior
keratoplasty (LALAK) will reduce the risks of post-operative complications such as
adhesions, glaucoma and cataract that are associated with pediatric penetrating keratoplasty
(PK).
keratoplasty (LALAK) will reduce the risks of post-operative complications such as
adhesions, glaucoma and cataract that are associated with pediatric penetrating keratoplasty
(PK).
There is a great need for lamellar keratectomy in the treatment of congenital opacities
because the rejection rate in pediatric PK is 4-5 times higher than in adults. In addition,
the intraocular inflammatory reaction in infants often leads to synechiae, glaucoma, and
cataract. Because LALAK does not penetrate the eye and preserves the host endothelium, it
could reduce the risk of these complications. Keratoplasty must be performed at this early
age to prevent amblyopia.
In this study, OCT-guided LALAK will be performed in patients whose vision is limited by
opacity in the anterior 2/3 of the cornea. The objective is to determine if LALAK will
provide an equal or better visual outcome than traditional PK without the associated
post-operative complications.
because the rejection rate in pediatric PK is 4-5 times higher than in adults. In addition,
the intraocular inflammatory reaction in infants often leads to synechiae, glaucoma, and
cataract. Because LALAK does not penetrate the eye and preserves the host endothelium, it
could reduce the risk of these complications. Keratoplasty must be performed at this early
age to prevent amblyopia.
In this study, OCT-guided LALAK will be performed in patients whose vision is limited by
opacity in the anterior 2/3 of the cornea. The objective is to determine if LALAK will
provide an equal or better visual outcome than traditional PK without the associated
post-operative complications.
Inclusion Criteria:
- Vision limited by opacity in the anterior 2/3 of the corneal stroma
- Posterior opacity and endothelial defect must be less than 1 mm in diameter
Exclusion Criteria:
- Presence of cataract
- Presence of adhesions of the iris or lens to the cornea
- Inability/unwillingness of parents to give informed consent
- Inability of parents to commit to required visits to complete the study
We found this trial at
1
site
Childrens Hospital Los Angeles Children's Hospital Los Angeles is a 501(c)(3) nonprofit hospital for pediatric...
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