Potential Use Of Brain Network Activation Analysis to Diagnose Major Depression
| Status: | Completed |
|---|---|
| Conditions: | Depression, Major Depression Disorder (MDD) |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 9/23/2012 |
| Start Date: | April 2012 |
| End Date: | April 2014 |
| Contact: | James Doorley, BA |
| Email: | jdoorley@partners.org |
| Phone: | 617-724-3222 |
Potential Use Of Brain Network Activation Analysis Using Evoked Response Potentials to Diagnose Major Depression and Assess Response to Antidepressant Treatment
The investigators are doing this study to find out if they can use electroencephalographic
(EEG) recordings, which measure brain waves, to predict response to antidepressant
treatments, as well as to distinguish patients who have depression from those who do not. In
particular the investigators want to test the usefulness of a new type of analysis of EEG
recordings called brain network activation or BNA. BNA allows to identify patterns of
activation in brain networks and to track their changes over time.
For Patients with Major Depressive Disorder
Inclusion Criteria:
- • Male and female outpatients, aged 18-55 years
- Subjects meeting full criteria for the diagnosis of current Major Depressive
Disorder (MDD) without psychotic features, as determined by clinical evaluation
and Mood Module of structured diagnostic interview (SCID), completed by the
study clinician.
- HAM-D17 score of 14 or higher
- Able to provide informed consent
- Right handed, normal (corrected) vision and normal hearing
Exclusion Criteria:
- • Other primary diagnoses including major depressive disorder with psychotic
features, bipolar disorder, schizoaffective disorder, schizophrenia, dementia,
attention deficit hyperactivity disorder (ADHD).
- Substance use disorder (abuse or dependence with active use within the last 6
months).
- Significant sensory deficits such as deafness or blindness.
- Severe or unstable medical illness, including history of closed head injury
resulting in loss of consciousness, seizure disorder; history of neurological
disorders.
- Pregnant or nursing females who are not using an accepted method of
contraception (birth control pill, IUD, combination of barrier methods)
- Clinically significant abnormal laboratory values or electrocardiogram For
Healthy Controls
Inclusion Criteria:
- Males and females, aged 18-55 years
- Subjects who do not meet full criteria for any of the major psychiatric diagnosis
including MDD, bipolar disorder, schizophrenia, substance abuse/dependence,
attention deficit hyperactivity disorder (ADHD), as determined by clinical evaluation
and structured diagnostic interview, completed by the study clinician.
- Right handed, normal (corrected) vision and normal hearing
Exclusion Criteria:
- Any current primary psychiatric, or medical condition determined to be clinically
significant.
- Current use of psychotropics or any medication with clinically significant central
nervous system effects.
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