Sleep Restriction and Obesity
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 12/7/2018 |
| Start Date: | July 2012 |
| End Date: | December 2020 |
| Contact: | Lisa Block |
| Email: | cplsleep@mayo.edu |
Insufficient sleep may be one of the most common, and most preventable, obesity risk factors.
The investigators wish to determine whether 14 nights of modest sleep restriction results in
increased energy balance, thus potentially increasing the risk of obesity. The investigators
hypothesize that sleep restriction will result in increased energy balance.
The investigators wish to determine whether 14 nights of modest sleep restriction results in
increased energy balance, thus potentially increasing the risk of obesity. The investigators
hypothesize that sleep restriction will result in increased energy balance.
Numerous studies have reported that self-reported short sleep duration is associated with
obesity and weight gain. Insufficient sleep may be one of the most common, and most
preventable, obesity risk factors. Given that sleep restriction is largely voluntary and
potentially correctable, understanding the mechanisms that link insufficient sleep to
positive energy balance and the development of obesity, particularly visceral obesity, is
crucial to clinical applications, public health policy, and informing future studies. The
investigators wish to determine whether 14 nights of modest sleep restriction results in
increased energy balance, thus potentially increasing the risk of obesity. The investigators
will combine energy balance, biomarker, and imaging data with state-of-the art sleep
monitoring to provide unambiguous data on the effects of sleep restriction on obesity.
Together, the investigators findings will help explain whether the reduced sleep duration in
the general population may be contributing to the current epidemic of obesity, and suggest
strategies to reduce this risk.
obesity and weight gain. Insufficient sleep may be one of the most common, and most
preventable, obesity risk factors. Given that sleep restriction is largely voluntary and
potentially correctable, understanding the mechanisms that link insufficient sleep to
positive energy balance and the development of obesity, particularly visceral obesity, is
crucial to clinical applications, public health policy, and informing future studies. The
investigators wish to determine whether 14 nights of modest sleep restriction results in
increased energy balance, thus potentially increasing the risk of obesity. The investigators
will combine energy balance, biomarker, and imaging data with state-of-the art sleep
monitoring to provide unambiguous data on the effects of sleep restriction on obesity.
Together, the investigators findings will help explain whether the reduced sleep duration in
the general population may be contributing to the current epidemic of obesity, and suggest
strategies to reduce this risk.
Inclusion Criteria:
- Age 18-40 years
- BMI of 18.5-30 kg/m2
- Not a current smoker or tobacco user
- No chronic medical or psychiatric disorders
- On no prescription medications other than second generation antihistamines
(cetirizine, fexofenadine, desloratadine, loratadine, etc), oral contraceptive pills,
or intrauterine devices
- History of normal sleep patterns, defined as nocturnal sleep duration of 6.5-8 hours
per night without regular daytime naps
Exclusion Criteria:
- The investigators will exclude subjects who have any medical or psychiatric disorders
- History of anxiety or depression
- Those taking any medications other than non-sedating antihistamines or oral
contraceptives will be excluded
- Those found to have depression on a depression screening tool (BDI-II) will be
excluded
- Current smokers will be excluded
- All female subjects will undergoing a screening pregnancy test and excluded if
positive
- Subjects found to have significant sleep disorders will be excluded
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