A Study of MEMP1972A in Patients With Allergic Asthma Inadequately Controlled on Inhaled Steroids And A Second Controller (COSTA)

Inclusion Criteria:

- Adult patients, 18 to 75 years of age inclusive

- Body weight >/= 40 kg

- Physician's diagnosis of asthma for at least 12 months

- Evidence of documented bronchodilator reversibility as defined by protocol

- Prebronchodilator FEV1 >/= 40% and
- Required daily use of ICS and a second controller for a minimum of 3 consecutive
months prior to Visit 1

- History of at least one protocol-defined asthma exacerbation in the 18 months prior
to Visit 1

- Inadequately controlled asthma despite compliance with asthma controller therapy

Exclusion Criteria:

- Asthma exacerbation requiring systemic steroids in the 30 days prior to Visit 1

- Pre-existing active lung disease other than asthma

- Any infection

- Clinically significant medical disease that is uncontrolled despite treatment or is
likely to require a change in therapy during study or is of unknown etiology

- Known immunodeficiency, including but not limited to HIV infection, regardless of
treatment status

- Current substance abuse

- Former smoker with >10 pack-year history or current smoker; former smokers must have
stopped smoking more than 12 months prior to Visit 1

- History of anaphylaxis

- Pregnant and lactating women